Moisture sorption by cellulose powders of varying crystallinity
Moisture sorption by cellulose powders of varying crystallinity
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DOI：
10.1016/j.ijpharm.2003.09.030
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发表时间：
2004-01-28
影响因子：
5.8
通讯作者：
Ek, R
中科院分区：
文献类型：
--
作者：
Mihranyan, A;Llagostera, AP;Ek, R
微晶纤维素中的水分可能导致对水分敏感的药物的稳定性问题。本研究的目的是探讨结晶度和表面积对纤维素粉末吸收水分的影响。制造不同结晶度的粉末，并在不同相对湿度下研究水分的吸收。通过X射线衍射、BET比表面积分析和扫描电子显微镜对纤维素粉末的结构进行了表征。吸湿率与纤维素结晶度和孔体积直接相关：具有较高结晶度的纤维素粉末在低于75%的相对湿度下显示出较低的吸湿率，而在较高湿度下，吸湿率可与最高结晶度的纤维素粉末的大孔体积的填充相关联。总之，在生产低水分MCC时，应充分考虑纤维素的结构。(C)2003 Elsevier B.V.保留所有权利。
Moisture in microcrystalline cellulose may cause stability problems for moisture sensitive drugs. The aim of this study was to investigate the influence of crystallinity and surface area on the uptake of moisture in cellulose powders. Powders of varying crystallinity were manufactured, and the uptake of moisture was investigated at different relative humidities. The structure of the cellulose powders was characterized by X-ray diffraction, BET surface area analysis, and scanning electron microscopy. Moisture uptake was directly related to the cellulose crystallinity and pore volume: Cellulose powders with higher crystallinity showed lower moisture uptake at relative humidities below 75%, while at higher humidities the moisture uptake could be associated with filling of the large pore volume of the cellulose powder of highest crystallinity. In conclusion, the structure of cellulose should be thoroughly considered when manufacturing low moisture grades of MCC. (C) 2003 Elsevier B.V. All rights reserved.