Cell adhesion molecules in the central nervous system
Cell adhesion molecules in the central nervous system
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DOI：
10.4161/cam.3.1.6773
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发表时间：
2009-01-01
影响因子：
3.2
通讯作者：
Takai, Yoshimi
中科院分区：
文献类型：
--
作者：
Togashi, Hideru;Sakisaka, Toshiaki;Takai, Yoshimi
细胞-细胞粘附分子在多种细胞的细胞间连接中起关键作用，包括神经元间突触和神经元-胶质细胞接触。功能研究表明，粘附分子参与神经网络形成的许多方面，如轴突导向、突触形成、突触结构调节和星形胶质细胞-突触接触。神经元和神经胶质细胞的连接复合物的组装的一些基本细胞生物学方面类似于上皮细胞。然而，神经元特异性连接机制是发挥神经元功能所必需的，如突触传递和可塑性。本文综述了细胞粘附分子在突触及突触与星形胶质细胞接触处的分布和功能。
Cell-cell adhesion molecules play key roles at the intercellular junctions of a wide variety of cells, including interneuronal synapses and neuron-glia contacts. Functional studies suggest that adhesion molecules are implicated in many aspects of neural network formation, such as axon-guidance, synapse formation, regulation of synaptic structure and astrocyte-synapse contacts. Some basic cell biological aspects of the assembly of junctional complexes of neurons and glial cells resemble those of epithelial cells. However, the neuron specific junctional machineries are required to exert neuronal functions, such as synaptic transmission and plasticity. In this review, we describe the distribution and function of cell adhesion molecules at synapses and at contacts between synapses and astrocytes.