BDNF induction with mild exercise in the rat hippocampus
BDNF induction with mild exercise in the rat hippocampus
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DOI：
10.1016/j.bbrc.2007.04.173
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发表时间：
2007-07-13
影响因子：
3.1
通讯作者：
Nishijima, Takeshi
中科院分区：
文献类型：
--
作者：
Soya, Hideaki;Nakamura, Toru;Nishijima, Takeshi
尽管慢性自愿体力活动已被证明可以增强动物海马脑源性神经营养因子（BDNF）的表达，但在跑步机上强迫运动的影响尚未得到充分研究。我们评估了不同跑步强度下的急性运动对 c-fos 和 BDNF 表达的诱导。 c-fos 的 mRNA（神经元激活的标志物）即使在低强度跑步（15 m/min）下也会上调，尽管其诱导似乎是强度依赖性的。另一方面，BDNF mRNA 和蛋白质的增加仅在低强度跑步时可见。中等强度跑步（25 m/min）会升高血乳酸和皮质酮水平，BDNF mRNA（而非其蛋白质）的诱导甚至会受到抑制。我们的研究显示了第一个证据，即通过压力最小的急性低强度运动，可以实现海马激活和 BDNF 表达，这支持了这样的观点：与更剧烈的运动相比，轻度运动可以对海马功能产生更大的益处。 (C) 2007 Elsevier Inc. 保留所有权利。
Although chronic voluntary physical activity has been shown to enhance hippocampal brain-derived neurotrophic factor (BDNF) expression in animals, the effects of forced exercise on a treadmill have not been fully investigated. We assessed induction of c-fos and BDNF expression with acute exercise at different running intensities. The mRNA for c-fos, a marker for neuronal activation, was up-regulated even under low-intensity running (15 m/min), although its induction appeared to be intensity dependent. On the other hand, increases in BDNF mRNA and protein were seen only at low-intensity running. At moderate-intensity running (25 m/min) which elevated blood lactate and corticosterone levels, induction of BDNF mRNA, but not its protein, was even depressed. Our study shows the first evidence that with an acute low-intensity exercise that is minimally stressful, hippocampal activation and BDNF expression can be achieved lending support to the idea that mild exercise could yield to greater benefits in hippocampal functions compared to the more strenuous forms. (C) 2007 Elsevier Inc. All rights reserved.