High sPLA2-IIA level is associated with eicosanoid metabolism in patients with bacterial sepsis syndrome
High sPLA2-IIA level is associated with eicosanoid metabolism in patients with bacterial sepsis syndrome
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DOI：
10.1371/journal.pone.0230285
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发表时间：
2020-03-11
期刊：
影响因子：
3.7
通讯作者：
Yusof, Yasmin Anum Mohd
中科院分区：
文献类型：
--
作者：
Ahmad, Nurul Saadah;Tan, Toh Leong;Yusof, Yasmin Anum Mohd
本研究的目的是确定细菌性脓毒症（BSS）患者分泌磷脂酶A2组IIA （sPLA2-IIA）与类二十酸途径代谢物之间的关系。测定确诊为细菌性脓毒症（BS, N = 45）、细菌性严重脓毒症/脓毒症休克（BSS/SS, N = 35）和健康者（N = 45）血清中sPLA2-IIA、20烷类前列腺素（PG）E2、PGD合成酶水平。分析细胞裂解液中环氧合酶(COX)-1和COX-2活性。BS和BSS/SS患者血清sPLA2-IIA、PGE2和PGDS水平较健康者显著升高（p< 0.05）。与健康受试者相比，BS患者的COX-2活性显著升高(p
The aim of this study was to determine the association between secretory phospholipase A2 group IIA (sPLA2-IIA) and eicosanoid pathway metabolites in patients with bacterial sepsis syndrome (BSS). Levels of sPLA2-IIA, eicosanoids prostaglandin (PG)E2, PGD synthase were quantified in the sera from patients confirmed to have bacterial sepsis (BS; N = 45), bacterial severe sepsis/septic shock (BSS/SS; N = 35) and healthy subjects (N = 45). Cyclooxygenase (COX)-1 and COX-2 activities were analyzed from cell lysate. Serum levels of sPLA2-IIA, PGE2, and PGDS increased significantly in patients with BS and BSS/SS compared to healthy subjects (p< 0.05). COX-2 activity was significantly increased in patients with BS compared to healthy subjects (p