Use of Cell-Free Circulating Schistosome DNA in Serum, Urine, Semen, and Saliva To Monitor a Case of Refractory Imported Schistosomiasis Hematobia
Use of Cell-Free Circulating Schistosome DNA in Serum, Urine, Semen, and Saliva To Monitor a Case of Refractory Imported Schistosomiasis Hematobia
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DOI：
10.1128/jcm.01219-13
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发表时间：
2013-10-01
影响因子：
9.4
通讯作者：
Chigusa, Yuichi
中科院分区：
文献类型：
--
作者：
Kato-Hayashi, Naoko;Yasuda, Mitsuko;Chigusa, Yuichi
本例输入性难治性血吸虫病突出了无细胞寄生虫DNA作为评估活动性血吸虫感染的诊断标记物的有效性。与尿液中卵子的迅速消失相反，寄生虫DNA在其他几种标本类型中仍然存在，即使在吡喹酮第四次治疗后也是如此。这一结果与膀胱活检样本中形态学完整的卵子的存在以及相应的症状相一致。
This case of imported refractory schistosomiasis has highlighted the usefulness of cell-free parasite DNA as a diagnostic marker to assess active schistosome infection. In contrast to the rapid disappearance of ova in urine, parasite DNA remained persistent in several other specimen types even after the fourth treatment with praziquantel. This result was consistent with the presence of morphologically intact ova in bladder biopsy samples and with the corresponding symptoms.