The role of weight control in the management of type 2 diabetes mellitus: Bariatric surgery.
The role of weight control in the management of type 2 diabetes mellitus: Bariatric surgery.
复制标题
体重控制在 2 型糖尿病治疗中的作用：减肥手术。
DOI：
10.1016/j.diabres.2023.110667
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发表时间：
2023
影响因子：
5.1
通讯作者：
Kindel,TammyLyn
中科院分区：
文献类型：
--
作者：
Xu,ThomasQ;Kindel,TammyLyn
糖尿病是美国的主要流行病之一。它与肥胖和多种代谢紊乱密切相关，导致长期发病率、死亡率和经济负担。虽然药物治疗一直是糖尿病管理的主要手段，但仍有很大一部分患者仅靠药物管理难以获得足够的血糖控制和长期体重控制。减肥手术是对抗糖尿病的有力工具，并通过多种途径影响葡萄糖稳态。虽然它确实提供了一种持久的减肥途径，但葡萄糖稳态的改善不仅受到减肥手术后体重减轻的影响。肠道激素分泌、胰岛素调节和肠道微生物组成的变化也影响这些手术如何改善葡萄糖稳态。通过改善对糖尿病的管理，包括心血管疾病在内的合并症也得到改善。在这篇文章中，我们将讨论减肥（代谢）手术的作用，因为它与长期减肥和减肥对改善糖尿病的影响有关。
Diabetes mellitus is one of the major epidemics in the United States. It is heavily associated with obesity and multiple metabolic derangements that lead to long term morbidity, mortality as well as financial burden. Although medical therapy has been the mainstay in the management of diabetes mellitus, there remains a large portion of this patient population which struggles to obtain adequate glycemic control and long-term weight control with medical management alone.Bariatric surgery is a powerful tool in combating diabetes mellitus and affects glucose homeostasis through a variety of pathways. While it does provide a durable pathway for weight loss, improvement in glucose homeostasis is not only affected by the weight loss seen after bariatric surgery. Changes in gut hormone secretion, insulin regulation, and gut microbial composition also affect how these operations improve glucose homeostasis. Through improvement in the management of diabetes mellitus, comorbidities including cardiovascular disease, in turn demonstrate improvement.In this article, we will discuss the role of bariatric (metabolic) surgery as it relates to long term weight loss and the impact that weight loss has on improvement in diabetes mellitus.