Impact of the caFFR-Guided Functional SYNTAX Score on Ventricular Tachycardia/Fibrillation Development in Patients With Acute Myocardial Infarction.
Impact of the caFFR-Guided Functional SYNTAX Score on Ventricular Tachycardia/Fibrillation Development in Patients With Acute Myocardial Infarction.
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DOI：
10.3389/fcvm.2022.807805
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发表时间：
2022
影响因子：
3.6
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中科院分区：
文献类型：
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探讨急性心肌梗死（AMI）患者冠状动脉病变（CAD）程度与室性心动过速/室颤（VT/VF）发生的关系。我们回顾性纳入了2017年7月至2020年7月在南方医院住院并接受经皮冠状动脉介入治疗（PCI）的705例AMI患者。采用Logistic回归分析和逐步回归分析筛选相关因素。绘制左侧和受试者工作特征曲线（ROC）分析，以观察SYNTAX评分（SS）/caFFR指导的功能SS（FSScaFFR）对事件VT/VF的区分能力。约58例（8.2%）患者发生危及生命的VT/VF。FSScaFFR（OR：1.155; 95% CI：1.047至1.273; p = 0.004）是AMI后VT/VF的独立预测因子。ROC分析显示，FSScaFFR对事件VT/VF的区分能力显著优于SS（0.759 vs.0.695，p < 0.0001）。根据急性心肌梗死与室速/室颤发生的间隔时间将室速/室颤患者分为两组。逻辑回归分析显示，FSScaFFR与早期和晚期VT/VF显著独立相关。AMI患者的VT/VF事件与SS和FSScaFFR评价的CAD严重程度密切相关。与SS相比，FSScaFFR与VT/VF具有更高的相关性，并且FSScaFFR被证明是AMI后事件VT/VF的独立相关因素。
To explore the relationship between the severity of coronary artery disease (CAD) and the occurrence of ventricular tachycardia/ventricular fibrillation (VT/VF) in patients with acute myocardial infarction (AMI). We retrospectively enrolled 705 patients with AMI, who were hospitalized and underwent percutaneous coronary intervention (PCI), in Nanfang Hospital from July 2017 to July 2020. Logistic regression analysis and backward stepwise approach were taken to select the correlation factors. The left and the receiver operating characteristic curves (ROC) analysis were plotted to observe the discriminative power of the SYNTAX score (SS)/caFFR-guided functional SS (FSScaFFR) on the incident VT/VF. About 58 (8.2%) patients experienced life-threatening VT/VF. The FSScaFFR (OR: 1.155; 95% CI: 1.047 to 1.273; p = 0.004) was an independent predictor of VT/VF after AMI. The ROC analysis showed that the discriminative power of FSScaFFR on the incident VT/VF was significantly better than SS (0.759 vs.0.695, p < 0.0001). Patients with VT/VF were categorized into 2 groups according to the interval between the onset of AMI and the VT/VF. The logistic regression analysis revealed that FSScaFFR was a significant independent correlation of early- and late-VT/VF. The incident VT/VF in patients with AMI is closely associated with the severity of CAD evaluated by SS and FSScaFFR. Compared to SS, FSScaFFR has a higher correlation with VT/VF, and FSScaFFR was demonstrated to be an independent correlation factor of incident VT/VF after AMI.