Pathological analysis of local delivery of paclitaxel via a polymer-coated stent
Pathological analysis of local delivery of paclitaxel via a polymer-coated stent
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DOI：
10.1161/hc3001.092037
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发表时间：
2001-07-24
期刊：
影响因子：
37.8
通讯作者：
Virmani, R
中科院分区：
文献类型：
--
作者：
Farb, A;Heller, PF;Virmani, R
背景-紫杉醇在体外可以抑制血管平滑肌的增殖，早期的研究表明紫杉醇可能有助于预防再狭窄。早期和晚期内膜。与紫杉醇支架有关的生长和局部血管病变尚未被充分研究。方法和结果-局部给药是通过球囊可膨胀不锈钢支架完成的，支架上涂有一种可交联的可生物降解聚合物硫酸软骨素和明胶(CSG)，含有不同剂量的紫杉醇。将含紫杉醇的CSG涂层支架(每个支架含紫杉醇42.0、20.2、8.6或1.5杯)、不含紫杉醇的CSG涂层支架和不含紫杉醇或CSG的非涂层支架分别植入新西兰大白兔的髂动脉内，28d后处死动物。支架支架处平均新生内膜厚度减少49%(P
Background-Paclitaxel can inhibit vascular smooth muscle proliferation in vitro, and early studies suggest that paclitaxel may be useful in preventing restenosis. Early and late intimal. growth and local vascular pathological changes associated with paclitaxel delivered via stents have not been fully explored.Methods and Results-Localized drug delivery was accomplished with balloon-expandable stainless steel stents coated with a cross-linked biodegradable polymer, chondroitin sulfate and gelatin (CSG), containing various doses of paclitaxel. CSG-coated stents with paclitaxel (42.0, 20.2, 8.6, or 1.5 mug of paclitaxel per stent), CSG-coated stents without paclitaxel, and uncoated stents (without paclitaxel or CSG) were deployed in the iliac arteries of New Zealand White rabbits, which were killed 28 days after implant. Mean neointimal thickness at stent strut sites was reduced 49% (P