An investigation of the activities of 3-hydroxykynureninase and kynurenine aminotransferase in the brain in Huntington's disease
An investigation of the activities of 3-hydroxykynureninase and kynurenine aminotransferase in the brain in Huntington's disease
复制标题
亨廷顿病大脑中 3-羟基犬尿氨酸酶和犬尿氨酸转氨酶的活性研究
DOI：
10.1007/bf01276566
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发表时间：
2005
期刊：
影响因子：
--
通讯作者：
G. Reynolds
中科院分区：
文献类型：
--
作者：
S. Pearson;A. Meldrum;G. Reynolds
以往的报道表明，亨廷顿病患者大脑中色氨酸/犬尿氨酸途径代谢产物浓度异常。其中包括3-羟基犬尿氨酸的增加和犬尿酸的增加和减少。在亨廷顿病患者和对照组的尸检脑组织中，测定了参与这些化合物代谢的两种酶--3-羟基犬尿氨酸酶和犬尿氨酸转氨酶的活性。
Previous reports have indicated abnormalities in the concentrations of metabolites of the tryptophan/kynurenine pathway in the brain in Huntington's disease. These have included an increase in 3-hydroxykynurenine and both increases and decreases in kynurenic acid. The activities of two enzymes involved in the metabolism of these compounds, 3-hydroxykynureninase and kynurenine aminotransferase, have been determined in post mortem brain tissue taken from Huntington's disease patients and control subjects.