Creating nanocrystallized chemotherapy: the differences in pressurized aerosol chemotherapy (PAC) via intracavitary (IAG) and extracavitary aerosol generation (EAG) regarding particle generation, morphology and structure
Creating nanocrystallized chemotherapy: the differences in pressurized aerosol chemotherapy (PAC) via intracavitary (IAG) and extracavitary aerosol generation (EAG) regarding particle generation, morphology and structure
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DOI：
10.7150/jca.39097
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发表时间：
2020-01-01
影响因子：
3.9
通讯作者：
Khosrawipour, Veria
中科院分区：
文献类型：
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作者：
Khosrawipour, Tanja;Schubert, Justyna;Khosrawipour, Veria
背景：纳米胶囊化是新药开发的一个有前途的领域。本研究的目的是目前使用的nanoclanization通过腹膜内nanoaerosol疗法（INAT）治疗腹膜metabolis.Methods：一个连续的气溶胶发生装置被用来雾化高浓度的阿霉素溶液在干燥的CO2环境。将产生的纳米气溶胶导入离体腹部模型中，并通过扫描电子显微镜（SEM）对气溶胶颗粒与放置的样品的碰撞进行进一步分析。SEM检测到迁移到不同locations.Results所造成的颗粒的结构变化：它是可能的可视化阿霉素气溶胶颗粒与表面的接触。较大的颗粒以及更靠近气溶胶产生室的颗粒与玻璃样品碰撞，产生液滴，而与气溶胶室距离更远的较小颗粒碰撞为高度浓缩的纳米晶体。结论：在最佳条件下，通过气溶胶产生装置可以形成纳米晶体。虽然纳米晶体的广泛的可能应用是可以想象的，但用药物颗粒进行表面涂覆是特别令人感兴趣的，因为它可以作为常规液体腹膜内化疗的替代方案。需要进一步的研究来调查化疗溶液的纳米化以及其物理和药理学性质和副作用。
Background: Nanocrystallization is a promising field for the development of new drugs. This study aims to present the use of nanocrystallization via intraperitoneal nanoaerosol therapy (INAT) for the treatment of peritoneal metastases.Methods: A continuous aerosol generation device was used to aerosolize a highly concentrated doxorubicin solution within a dry CO2 environment. The produced nanoaerosol was directed into an ex vivo abdominal model and collision of aerosol particles with placed samples was subject to further analysis via scanning-electron microscopy (SEM). SEM detected structural changes of particles caused by migration to different locations.Results: It was possible to visualize the contact of doxorubicin aerosol particles with the surface. Larger particles as well as particles closer to the aerosol generation chamber collided with the glass sample creating liquid drops, while smaller particles with more distance to the aerosol chamber collided as highly concentrated nanocrystals. The amount of nanocrystal particles outweighed the amount of fluid aerosol particles by far.Conclusions: Under optimal conditions, the formation of nanocrystals via aerosol creation device is possible. While a wide range of possible applications of nanocrystals is conceivable, surface coating with drug particles is especially interesting as it may serve as an alternative to conventional liquid intraperitoneal chemotherapy. Further studies are required to investigate nanocrystallization of chemotherapeutic solutions as well as its physical and pharmacological properties and side effects.