Discerning primary and secondary factors responsible for clinical fatigue in multisystem diseases.
Discerning primary and secondary factors responsible for clinical fatigue in multisystem diseases.
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DOI：
10.3390/biology3030606
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发表时间：
2014-09-22
期刊：
影响因子：
4.2
通讯作者：
Toth M
中科院分区：
文献类型：
--
作者：
Maughan D;Toth M
疲劳是许多急慢性疾病的常见症状，包括肌痛性脑脊髓炎/慢性疲劳综合征、多发性硬化症、心力衰竭、癌症和许多其他疾病。在这些多系统疾病中，增强疲劳的生理决定因素包括代谢、神经和肌原纤维适应的组合。以前的研究集中在骨骼肌特有的适应及其在疲劳中的作用。然而，大多数人忽视了缺乏体力活动在评估疾病综合征方面的作用，而通过解除条件，这可能会导致症状性疲劳。在这篇评论中，我们简要回顾与疾病相关的肌肉表型，看看它们是与原发病有关，还是由于体力活动减少而发展为继发性疾病。了解骨骼肌在这些条件下适应的病因学及其对疲劳症状的贡献，对于理解运动康复作为一种干预措施缓解疲劳的生理诱因的作用是重要的。
Fatigue is a common symptom of numerous acute and chronic diseases, including myalgic encephalomyelitis/chronic fatigue syndrome, multiple sclerosis, heart failure, cancer, and many others. In these multi-system diseases the physiological determinants of enhanced fatigue encompass a combination of metabolic, neurological, and myofibrillar adaptations. Previous research studies have focused on adaptations specific to skeletal muscle and their role in fatigue. However, most have neglected the contribution of physical inactivity in assessing disease syndromes, which, through deconditioning, likely contributes to symptomatic fatigue. In this commentary, we briefly review disease-related muscle phenotypes in the context of whether they relate to the primary disease or whether they develop secondary to reduced physical activity. Knowledge of the etiology of the skeletal muscle adaptations in these conditions and their contribution to fatigue symptoms is important for understanding the utility of exercise rehabilitation as an intervention to alleviate the physiological precipitants of fatigue.