Fructose consumption and the risk of kidney stones
Fructose consumption and the risk of kidney stones
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DOI：
10.1038/sj.ki.5002588
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发表时间：
2008-01-01
影响因子：
19.6
通讯作者：
Curhan, G. C.
中科院分区：
文献类型：
--
作者：
Taylor, E. N.;Curhan, G. C.
在过去的几十年里，果糖的消费量显著增加。这种摄入可能会增加尿中钙、草酸盐、尿酸和其他与肾结石风险相关的因素的排泄。我们在护士健康研究I（NHS I）（93 730名老年女性）、护士健康研究II（NHS II）（101 824名年轻女性）和卫生专业人员随访研究（45 984名男性）中前瞻性地研究了果糖摄入量与肾结石发病率之间的关系。每4年使用食物频率问卷来评估游离果糖和蔗糖的摄入量。总果糖摄入量计算为游离果糖加上一半的蔗糖摄入量，并表示为总能量的百分比。考克斯比例风险回归校正年龄，体重指数（BMI），噻嗪类药物的使用，热量摄入，和其他饮食因素。在48年的随访中，我们记录了4902例肾结石。在所有三个研究组中，总果糖摄入量最高的参与者与摄入量最低的参与者相比，肾结石的多变量相对风险显著增加。游离果糖摄入量也与风险增加有关。在任何队列中，非果糖碳水化合物与风险增加无关。我们的研究表明，果糖摄入量与肾结石发病风险增加独立相关。
Fructose consumption has markedly increased over the past decades. This intake may increase the urinary excretion of calcium, oxalate, uric acid, and other factors associated with kidney stone risk. We prospectively examined the relationship between fructose intake and incident kidney stones in the Nurses' Health Study I (NHS I) (93 730 older women), the Nurses' Health Study II (NHS II) (101 824 younger women), and the Health Professionals Follow-up Study (45 984 men). Food frequency questionnaires were used to assess free fructose and sucrose intake every 4 years. Total-fructose intake was calculated as free fructose plus half the intake of sucrose, and expressed as percentage of total energy. Cox proportional hazard regressions were adjusted for age, body mass index (BMI), thiazide use, caloric intake, and other dietary factors. We documented 4902 incident kidney stones during a combined 48 years of follow-up. The multivariate relative risks of kidney stones significantly increased for participants in the highest compared to the lowest quintile of total-fructose intake for all three study groups. Free-fructose intake was also associated with increased risk. Non-fructose carbohydrates were not associated with increased risk in any cohort. Our study suggests that fructose intake is independently associated with an increased risk of incident kidney stones.