Signal transduction: Rhapsody in G proteins
Signal transduction: Rhapsody in G proteins
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DOI：
10.1038/23594
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发表时间：
1999
期刊：
影响因子：
64.8
通讯作者：
J. Bos;F. Zwartkruis
中科院分区：
文献类型：
--
作者：
J. Bos;F. Zwartkruis
鸟嘌呤核苷酸结合蛋白是一种分子开关，它可以将细胞表面接收到的信号转换为内部蛋白质的生物反应。有两种类型的G蛋白-异源三聚体G蛋白和小G蛋白酶。一项新的研究表明，一种名为Rap 1的众所周知的小GTP酶通过一种名为Rap 1GAPII的GTP酶激活蛋白，由一种异源三聚体G蛋白调节。
Guanine-nucleotide-binding proteins are molecular switches that transduce the signals received at a cell's surface to elicit a biological response from the proteins inside. There are two types of G protein — the heterotrimeric G proteins and the small GTPases. New research shows that a well-known small GTPase called Rap1 is regulated by a heterotrimeric G protein, via a GTPase-activating protein called Rap1GAPII.