Perivascular neuritic dystrophy associated with cerebral amyloid angiopathy in Alzheimer's disease.
Perivascular neuritic dystrophy associated with cerebral amyloid angiopathy in Alzheimer's disease.
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DOI：
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发表时间：
2008
影响因子：
1.4
通讯作者：
Kenichi Oshima;H. Uchikado;D. Dickson
中科院分区：
文献类型：
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作者：
Kenichi Oshima;H. Uchikado;D. Dickson
脑淀粉样血管病（CAA）影响脑膜和实质血管，在阿尔茨海默病（AD）中很常见。在一些血管中，CAA伴有受影响血管周围的局部神经性营养不良。本研究的目的是评估初级视觉和视觉关联皮层血管周围神经性营养不良的分布和严重程度。对31例AD合并重度CAA患者的关联皮层（Brodmann区18）和原发皮层（Brodmann区17）进行tau和Abeta双标记免疫组化，评分血管周围神经营养不良和Abeta沉积的严重程度。血管周围tau神经营养不良评分在视觉关联皮层明显低于初级视觉皮层。另一方面，两种皮层的血管周围β评分没有差异。初级和联合皮层的血管周围tau的严重程度和血管周围β评分之间存在正相关。结果表明，局部神经元环境比内在血管疾病的严重程度更能决定血管周围神经炎病理的严重程度和性质，并提示血管周围淀粉样蛋白沉积（所谓的血管病变）与血管周围神经炎营养不良之间存在密切联系。
Cerebral amyloid angiopathy (CAA) affects both leptomeningeal and parenchymal blood vessels and is common in Alzheimer's disease (AD). In some vessels, CAA is accompanied by localized neuritic dystrophy around the affected blood vessel. The aim of this study was to assess the distribution and severity of perivascular neuritic dystrophy in primary visual and visual association cortices. The severity of perivascular neuritic dystrophy and Abeta deposition was scored in an association cortex (Brodmann area 18) and a primary cortex (Brodmann area 17) with double labeling immunohistochemistry for tau and Abeta in 31 cases of AD with severe CAA. The perivascular tau neuritic dystrophy score was significantly worse in visual association cortex than in primary visual cortex. On the other hand, there was no difference in the perivascular Abeta score between the two cortices. There were positive correlations between the severity of perivascular tau and perivascular Abeta scores for both primary and association cortices. The results suggest that the local neuronal environment determines the severity and nature of the perivascular neuritic pathology more than the severity of the intrinsic vascular disease and suggest a close association between perivascular amyloid deposits, so-called dyshoric angiopathy, and perivascular neuritic dystrophy.