Role of the Transcription Factor MAFA in the Maintenance of Pancreatic β-Cells.
Role of the Transcription Factor MAFA in the Maintenance of Pancreatic β-Cells.
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DOI：
10.3390/ijms23094478
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发表时间：
2022-04-19
影响因子：
5.6
通讯作者：
中科院分区：
文献类型：
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作者：
胰腺 β 细胞专门负责正确调节血糖。成熟 β 细胞表型的维持对于葡萄糖代谢至关重要，β 细胞衰竭会导致糖尿病。最近的研究提供了强有力的证据，表明β细胞的成熟表型是由几种转录因子维持的。这些因子也是胰腺发育过程中 β 细胞从内分泌前体分化或从未成熟 β 细胞成熟所必需的。由于这些因子的减少或缺失会导致β细胞衰竭和糖尿病，因此诱导这些转录因子的上调或抑制下调将有利于糖尿病和干细胞生物学的研究。在这里，我们讨论这样一个因子，即转录因子 MAFA。 MAFA是一种碱性亮氨酸拉链家族转录因子，可以与PDX1和NEUROD1一起激活β细胞中胰岛素的表达。 MAFA 确实不仅对于维持胰岛素表达而且对于维持成体 β 细胞的功能也是不可或缺的。随着 2 型糖尿病中 MAFA 的缺失，β 细胞无法维持其成熟表型并发生去分化。在本文中，我们首先简要总结了MAFA在β细胞中的功能作用，然后重点讨论了MAFA调节细胞命运转换的分子机制。
Pancreatic β-cells are specialized to properly regulate blood glucose. Maintenance of the mature β-cell phenotype is critical for glucose metabolism, and β-cell failure results in diabetes mellitus. Recent studies provide strong evidence that the mature phenotype of β-cells is maintained by several transcription factors. These factors are also required for β-cell differentiation from endocrine precursors or maturation from immature β-cells during pancreatic development. Because the reduction or loss of these factors leads to β-cell failure and diabetes, inducing the upregulation or inhibiting downregulation of these transcription factors would be beneficial for studies in both diabetes and stem cell biology. Here, we discuss one such factor, i.e., the transcription factor MAFA. MAFA is a basic leucine zipper family transcription factor that can activate the expression of insulin in β-cells with PDX1 and NEUROD1. MAFA is indeed indispensable for the maintenance of not only insulin expression but also function of adult β-cells. With loss of MAFA in type 2 diabetes, β-cells cannot maintain their mature phenotype and are dedifferentiated. In this review, we first briefly summarize the functional roles of MAFA in β-cells and then mainly focus on the molecular mechanism of cell fate conversion regulated by MAFA.
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DOI：
10.1016/j.beem.2015.09.006
发表时间：
2015-12
期刊：
Best practice & research. Clinical endocrinology & metabolism
影响因子：
--
作者：
El Khattabi I;Sharma A
通讯作者：
Sharma A
影响因子：
3.7
作者：
Eto K;Nishimura W;Oishi H;Udagawa H;Kawaguchi M;Hiramoto M;Fujiwara T;Takahashi S;Yasuda K
通讯作者：
Yasuda K
影响因子：
7.7
作者：
Cyphert, Holly A.;Walker, Emily M.;Stein, Roland
通讯作者：
Stein, Roland
影响因子：
5.8
作者：
Aguayo-Mazzucato, Cristina;Dilenno, Amanda;Bonner-Weir, Susan
通讯作者：
Bonner-Weir, Susan
影响因子：
--
作者：
Galloway, Jamie R.;Bethea, Maigen;Hunter, Chad S.
通讯作者：
Hunter, Chad S.