Dihydropyridine receptor and ryanodine receptor gene expression in long-term denervated rat muscles.
Dihydropyridine receptor and ryanodine receptor gene expression in long-term denervated rat muscles.
复制标题
长期去神经大鼠肌肉中二氢吡啶受体和兰尼碱受体基因表达。
DOI：
10.1006/bbrc.1997.7712
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发表时间：
1997
期刊：
影响因子：
--
通讯作者：
Palade,P
中科院分区：
文献类型：
--
作者：
Pereon,Y;Sorrentino,V;Dettbarn,C;Noireaud,J;Palade,P
Following disruption of the nerve supply, extensor digitorum longus (EDL) and soleus (SOL) muscles in rats are known to exhibit alterations in excitation–contraction coupling. After total RNA isolation from the denervated and the contralateral control muscles performed at 25 and 50 days following denervation, RNase protection assays were carried out with four cDNA probes specific for the skeletal and cardiac isoforms of both the DHPR α1-subunit and the RyR. Long-term denervation increased the expression of the mRNA for skeletal DHPR and skeletal RyR in SOL muscle, but it also significantly increased the expression of the mRNA for the cardiac isoform of the DHPR α1 subunit in EDL muscle.
