Significant associations between hemostatic/fibrinolytic systems and accumulation of cardiovascular risk factors in Japanese elementary school children.
Significant associations between hemostatic/fibrinolytic systems and accumulation of cardiovascular risk factors in Japanese elementary school children.
复制标题
日本小学生的止血/纤溶系统与心血管危险因素积累之间存在显着关联。
DOI：
10.1097/mbc.0000000000000187
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发表时间：
2015
影响因子：
1.1
通讯作者：
Sumazaki R.
中科院分区：
文献类型：
--
作者：
Lin L;Horigome H;Kato Y;Kikuchi T;Nakahara S;Sumazaki R.
本研究的目的是在正常学龄儿童人群中建立止血/纤溶标志物的参考值，并探讨其与体质和心血管危险因素的关系。这项研究包括148名9-10岁的健康日本儿童(男73名，女75名)。在隔夜禁食后的第二天早晨进行实验室检查，包括血瘦素、超敏C反应蛋白、止血和纤溶指标[纤溶酶原激活物抑制物1、凝血因子VII、凝血因子X、纤维蛋白原、蛋白C、蛋白S]，以及常见的生化指标。我们调查了这些标记的平均值、第10、50和90百分位数。所有参数在两组之间进行比较，即体重指数(BMI)大于或等于90%且BMI小于90%的组，以及基于心血管危险因素数量的亚组之间的比较。采用多元线性回归分析这些血液学参数与代谢综合征(METS)相关成分的相关性。BMI90百分位数及以上组血丙氨酸氨基转移酶(ALT)、尿酸、瘦素、超敏C反应蛋白(hs-CRP)及所有凝血/纤溶指标(PAI-1、FVII、Fx、Fbg、蛋白C、S蛋白)均显著高于正常对照组，且随着心血管危险因素的增多而升高。多元线性回归分析表明，这些值与蛋氨酸相关的一个或多个成分有关。获得日本学龄儿童止血/纤溶指标的参考值。在正常的日本学龄儿童中，许多止血/纤溶标记物与BMI和心血管危险因素的积累显著相关。
The aim of this study was to establish the reference values of hemostatic/fibrinolytic markers and investigate their relationship with physical constitution and cardiovascular risk factors in a normal schoolchildren population. This study comprised 148 healthy Japanese children aged 9–10 years (males 73; females 75). We performed laboratory tests including blood levels of leptin, high-sensitive C-reactive protein (hs-CRP), hemostatic and fibrinolytic markers [plasminogen activator inhibitor 1 (PAI-1), coagulation factor VII (FVII), coagulation factor X (FX), fibrinogen (Fbg), protein C, protein S], as well as common biochemical markers in the morning after an overnight fast. We investigated the mean, 10th, 50th and 90th percentile values of these markers. All parameters were compared between two groups, that is those with body mass index (BMI) 90th percentile or higher and BMI less than 90th percentile, and between subgroups based on the number of cardiovascular risk factors. Multiple-linear regression was used to assess associations between these hematological parameters and the components related to metabolic syndrome (MetS). Alanine aminotransferase (ALT), uric acid, leptin, hs-CRP, and all hemostatic/fibrinolytic markers (PAI-1, FVII, FX, Fbg, protein C, protein S) tested were significantly higher in the group with BMI 90th percentile or higher, and increased with accumulation of cardiovascular risk factors. Multiple-linear regression analysis showed that these values were associated with one or more components related to MetS. Reference values of hemostatic/fibrinolytic markers in Japanese schoolchildren were obtained. Many hemostatic/fibrinolytic markers showed significant association with BMI and accumulation of cardiovascular risk factors in normal Japanese schoolchildren.