Reperfusion after ischemic stroke is associated with reduced brain edema
Reperfusion after ischemic stroke is associated with reduced brain edema
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DOI：
10.1177/0271678x17720559
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发表时间：
2018-10-01
影响因子：
6.3
通讯作者：
Kimberly, W. Taylor
中科院分区：
文献类型：
--
作者：
Irvine, Hannah J.;Ostwaldt, Ann-Christin;Kimberly, W. Taylor
快速血运重建对急性卒中非常有效，但动物研究表明，再灌注水肿可能会削弱其有益作用。我们研究了回波平面成像溶栓评价试验（EPITHET）和采用栓子切除术（MR RESCUE）队列的卒中凝块机械回收和再通患者中再灌注和水肿之间的关系。再灌注百分比测量为基线和随访（EPITHET为第3-5天; MR RESCUE为第6-8天）之间灌注加权成像病变体积的差异。在随访MRI上量化中线移位（MLS）和肿胀体积。我们发现再灌注与MLS减少相关（EPITHET：斯皮尔曼=-0.46; P
Rapid revascularization is highly effective for acute stroke, but animal studies suggest that reperfusion edema may attenuate its beneficial effects. We investigated the relationship between reperfusion and edema in patients from the Echoplanar Imaging Thrombolysis Evaluation Trial (EPITHET) and Mechanical Retrieval and Recanalization of Stroke Clots Using Embolectomy (MR RESCUE) cohorts. Reperfusion percentage was measured as the difference in perfusion-weighted imaging lesion volume between baseline and follow-up (day 3-5 for EPITHET; day 6-8 for MR RESCUE). Midline shift (MLS) and swelling volume were quantified on follow-up MRI. We found that reperfusion was associated with less MLS (EPITHET: Spearman =-0.46; P