Determinants of mammalian nucleolar architecture.
Determinants of mammalian nucleolar architecture.
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DOI：
10.1007/s00412-015-0507-z
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发表时间：
2015-09
期刊：
影响因子：
1.6
通讯作者：
Baserga SJ
中科院分区：
文献类型：
--
作者：
Farley KI;Surovtseva Y;Merkel J;Baserga SJ
核仁负责产生核糖体，核糖体是合成细胞所需的所有蛋白质的重要机器。人类核仁的结构是高度动态的，与其在核糖体生物合成中的功能直接相关。尽管这种细胞器很重要，但核仁结构和功能之间的复杂关系在很大程度上仍未被探索。细胞如何控制核仁的形成和功能？制造功能性核仁的最低要求是什么？在这里，我们回顾了目前已知的关于哺乳动物核仁组织区 (NOR) 核仁形成的知识，这可以通过观察每次细胞分裂期间核仁的溶解和重组来研究。此外，可以通过分析核仁功能的改变如何体现在核仁结构的差异中来检查核仁。此外，核仁结构和功能的变化与癌症相关，凸显了研究核仁形成决定因素的重要性。
The nucleolus is responsible for the production of ribosomes, essential machines which synthesize all proteins needed by the cell. The structure of human nucleoli is highly dynamic and is directly related to its functions in ribosome biogenesis. Despite the importance of this organelle, the intricate relationship between nucleolar structure and function remains largely unexplored. How do cells control nucleolar formation and function? What are the minimal requirements for making a functional nucleolus? Here we review what is currently known regarding mammalian nucleolar formation at nucleolar organizer regions (NORs), which can be studied by observing the dissolution and reformation of the nucleolus during each cell division. Additionally, the nucleolus can be examined by analyzing how alterations in nucleolar function manifest in differences in nucleolar architecture. Furthermore, changes in nucleolar structure and function are correlated with cancer, highlighting the importance of studying the determinants of nucleolar formation.