Cassane diterpenes from the seed kernels of Caesalpinia sappan
Cassane diterpenes from the seed kernels of Caesalpinia sappan
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DOI：
10.1016/j.phytochem.2015.12.018
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发表时间：
2016-02-01
期刊：
影响因子：
3.8
通讯作者：
Awale, Suresh
中科院分区：
文献类型：
--
作者：
Nguyen, Hai Xuan;Nhan Trung Nguyen;Awale, Suresh
从越南苏木种仁中分离得到8个结构不同的蜡烷二萜化合物，命名为Tomocins A-H。其结构经广泛的核磁共振和圆二色谱确证。在分离的化合物中，Tomocin A、Panginin A、F和H在营养缺乏条件下对PANC-1人胰腺癌细胞表现出轻微的优先杀伤作用，而在正常营养丰富的条件下不产生毒性。(C)2016爱思唯尔有限公司。保留所有权利。
Eight structurally diverse cassane diterpenes named tomocins A-H were isolated from the seed kernels of Vietnamese Caesalpinia sappan Linn. Their structures were determined by extensive NMR and CD spectroscopic analysis. Among the isolated compounds, tomocin A, phanginin A, F, and H exhibited mild preferential cytotoxicity against PANC-1 human pancreatic cancer cells under nutrition-deprived condition without causing toxicity in normal nutrient-rich conditions. (C) 2016 Elsevier Ltd. All rights reserved.