What is Cooperativity?
What is Cooperativity?
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DOI：
10.1002/anie.200902490
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发表时间：
2009-01-01
影响因子：
16.6
通讯作者：
Anderson, Harry L.
中科院分区：
文献类型：
--
作者：
Hunter, Christopher A.;Anderson, Harry L.
七鳃鳗掌握了超分子自组装和变构配体结合之间联系的线索。自组装结构中的螯合协同性导致变性行为与变构配体结合难以区分。螯合效应是正协作性最常见的起源，但其重要性却被广泛忽视。©2009 Wiley-VCH Verlag GmbH and Co. KGaA。
The lamprey holds the clue to the link between supramolecular self-assembly and allosteric ligand binding. Chelate cooperativity in self-assembled structures results in denaturation behavior that is indistinguishable from allosteric ligand binding. The chelate effect is the most common origin of positive cooperativity, yet its significance has been widely overlooked. © 2009 Wiley-VCH Verlag GmbH and Co. KGaA.