Sustained attention-deficit confirmed in euthymic bipolar disorder but not in first-degree relatives of bipolar patients or euthymic unipolar depression
Sustained attention-deficit confirmed in euthymic bipolar disorder but not in first-degree relatives of bipolar patients or euthymic unipolar depression
复制标题
DOI：
10.1016/j.biopsych.2004.11.007
复制
发表时间：
2005-01-15
影响因子：
10.6
通讯作者：
Goodwin, GM
中科院分区：
文献类型：
--
作者：
Clark, L;Kempton, MJ;Goodwin, GM
工作背景：认知功能障碍持续存在于双相情感障碍的正常期，可能是潜在神经病理学和疾病易感性的标志。本研究旨在复制正常心境双相情感障碍患者的持续注意力缺陷，并调查双相情感障碍先证者的一级亲属和重度抑郁症缓解患者的持续注意力。采用快速视觉信息加工（RVIP）任务，对15名双相情感障碍患者和15名对照者的持续注意力进行了测量。结果：实验1中心境正常的双相情感障碍患者存在持续性注意缺陷，而心境正常的双相情感障碍患者和双相情感障碍先证者亲属的持续性注意缺陷差异无统计学意义。持续注意力缺陷在缓解期复发性抑郁症患者中不存在，在双相先证者的一级亲属中也不存在。因此，在情感正常的双相情感障碍患者中确认的异常可能是双相情感障碍疾病的结果。然而，未来的亲属研究将需要更大的样本量，以排除或利用小的遗传效应。
Background: Cognitive dysfunction persists in the euthymic phase of bipolar disorder and may provide a marker of underlying neuropathology and disease vulnerability. This study aimed to replicate a deficit in sustained attention in euthymic bipolar patients and investigate sustained attention in first-degree relatives of bipolar probands and in remitted patients with major depressive disorder.Methods: The rapid visual information processing (RVIP) task was used to measure sustained attention in 15 euthymic patients with bipolar disorder and 15 control subjects in experiment 1 and in 27 first-degree relatives of bipolar, 15 remitted patients with major depressive disorder, and 46 control subjects in experiment 2.Results: Sustained attention deficit was confirmed in the euthymic bipolar patients in experiment 1, but the deficit was not statistically significant in remitted major depressed patients or in the relatives of bipolar probands.Conclusions: A deficit of sustained attention is not present in patients with recurrent major depression tested during remission nor is it discriminable in the first-degree relatives of bipolar probands. Thus, the confirmed abnormality in euthymic bipolar patients may be acquired as a consequences of bipolar illness. However, future studies of relatives will require larger samples sizes to exclude or utilize small genetic effects.