Prevalence, risk factors and impact of gastroesophageal reflux disease symptoms: A population-based study in South China
Prevalence, risk factors and impact of gastroesophageal reflux disease symptoms: A population-based study in South China
复制标题
DOI：
10.1080/00365520510015610
复制
发表时间：
2005-07-01
影响因子：
1.9
通讯作者：
Hu, PJ
中科院分区：
文献类型：
--
作者：
Chen, MH;Xiong, LH;Hu, PJ
目标。华南地区胃食管反流病（GERD）的流行病学资料较少。本研究的目的是评估华南地区胃食管反流症状的患病率，并评估其对健康相关生活质量的影响。材料和方法。在华南地区进行面对面访谈，使用经过验证的中文版反流疾病问卷来评估反流症状的患病率。对18 ~ 90岁的常住居民按城市和郊区分层随机整群抽样。使用中文版SF-36评估胃食管反流症状对健康相关生活质量的影响。结果。共调查了3338名居民（1468 M, 1870 F）。应答者的平均年龄为42.6±16.4岁；有效率为95%。每周至少发生一次胃灼热和/或嗳酸的发生率为6.2%。根据本研究的定义，华南地区经年龄和性别调整的GERD症状点患病率为2.3% （95% CI, 1.8%, 2.8%）。男性（2.6%）和女性（2.4%）之间的患病率没有差异，年龄和反流症状患病率之间没有显著关联。离婚/丧偶/分居受试者（OR 4.61; 95% CI, 2.15%, 9.89%）和工作负担重的受试者（OR 3.43, 95% CI, 1.72%, 6.84%）报告反流胃食管反流症状的可能性显著增加。与一般人群相比，有反流胃食管反流症状的受试者在生活质量方面经历了相当大的损害。结论。中国南方反流症状的患病率远低于西方国家的报道。胃食管反流对生活质量有负面影响。
Objective. There are few data on the epidemiology of gastroesophageal reflux disease (GERD) in South China. The aim of this study was to assess the prevalence of GERD symptoms in South China and to evaluate the impact on health-related quality of life. Material and methods. A face-to-face interview was carried out in South China using a validated Chinese version of the Reflux Disease Questionnaire to assess the prevalence of GERD symptoms. A randomly clustered sampling of permanent inhabitants aged 18 to 90 years was carried out under stratification of urban and suburban areas. The impact of GERD symptoms on health-related quality of life was evaluated using the Chinese version of SF-36. Results. A total of 3338 residents (1468 M, 1870 F) were investigated. Mean age of the responders was 42.6 +/- 16.4 years; response rate was 95%. The prevalence of heartburn and/or acid eructation occurring at least weekly was 6.2%. The age- and gender-adjusted point prevalence of GERD symptoms in South China is 2.3% (95% CI, 1.8%, 2.8%) according to the definition in this study. There was no difference in prevalence between male (2.6%) and female (2.4%) subjects and there was no significant association between age and prevalence of GERD symptoms. Divorced/widowed/separated subjects (OR 4.61; 95% CI, 2.15%, 9.89%) and subjects with a heavy burden of work (OR 3.43, 95% CI, 1.72%, 6.84%) were significantly more likely to report GERD symptoms. As compared with the general population, subjects with GERD symptoms experienced considerable impairment in quality of life. Conclusions. The prevalence of GERD symptoms in South China was much lower than that reported in Western countries. GERD had a negative impact on quality of life.