Nonspecificity induces chiral specificity in the folding transition of giant DNA.
Nonspecificity induces chiral specificity in the folding transition of giant DNA.
复制标题
非特异性会导致巨型 DNA 折叠转变中的手性特异性。
DOI：
10.1021/ja036745x
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发表时间：
2003
影响因子：
15
通讯作者：
K. Yoshikawa
中科院分区：
文献类型：
--
作者：
M. Ito;A. Sakakura;N. Miyazawa;S. Murata;K. Yoshikawa
全有或全无类型的DNA折叠从卷曲到球状的转变可以通过三胺的手性来区分。对单分子的荧光显微镜观察表明，从天然碱性氨基酸(L-赖氨酸或L-精氨酸)获得的三肽能以低于d-异构体的浓度紧凑DNA分子。在折叠的DNA分子上的AFM图像中发现了纳米级的珠子。
The all-or-none type DNA folding transition from a coil to globule can be differentiated by the chirality of the triamines. The fluorescent microscope observation on single DNA molecules makes it clear that the tripeptides obtained from naturally occurring basic amino acids (l-lysine or l-arginine) can compact DNA molecules at concentrations lower than those from d-isomers. Nanometer-sized beads are found in the AFM images on the folded DNA molecule.