Invited Commentary: Interaction Between Diet and Chemical Exposures.
Invited Commentary: Interaction Between Diet and Chemical Exposures.
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特邀评论：饮食与化学品暴露之间的相互作用。
DOI：
10.1093/aje/kwz152
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发表时间：
2019
影响因子：
5
通讯作者：
Wise,LaurenA
中科院分区：
文献类型：
--
作者：
Wesselink,AmeliaK;Hatch,ElizabethE;Wise,LaurenA
越来越多的文献表明，包括饮食在内的可变因素的变化可以抵消化学品接触对发育和生殖健康的毒性影响。在本期杂志中，Gaskins等人（Am J Epidemiol. 2019;000（000）：000-000）提供了支持这一假设的数据。具体来说，使用马萨诸塞州波士顿304名寻求生育治疗的女性的队列数据，他们发现暴露于环境空气污染物的女性生育治疗成功率较低，但只有当她们补充叶酸<800 μg/天时。在补充叶酸≥800 μg/天的女性中未观察到相关性。这种相互作用对公共卫生的重要性很高：饮食和膳食补充剂的摄入是可改变的因素，而暴露于空气污染则不那么重要。虽然这个研究问题是建立在一个强有力的生物学假设相关的表观遗传修饰，氧化应激和炎症，这项研究提出了几个关键问题。在这篇评论中，我们讨论了暴露指标之间相互作用的不一致性，叶酸摄入量未测量的混杂的可能性，以及在叶酸摄入量较低和/或暴露于空气污染较高的人群中检查这种关联的重要性。
A growing literature indicates that changes in modifiable factors, including diet, can counteract the toxic developmental and reproductive health effects of chemical exposures. In this issue of theJournal, Gaskins et al. (Am J Epidemiol. 2019;000(000):000–000) present data supporting this hypothesis. Specifically, using data on a cohort of 304 women seeking fertility treatment in Boston, Massachusetts, they found that women with higher exposure to ambient air pollutants had lower fertility treatment success but only when they also consumed <800 μg/day of supplemental folate. No association was observed among women consuming ≥800 μg/day of supplemental folate. The public health importance of this interaction is high: Diet and dietary supplement intake are modifiable factors, whereas exposure to air pollution is less so. While this research question is grounded in a strong biological hypothesis related to epigenetic modifications, oxidative stress, and inflammation, this study raises several key questions. In this commentary, we discuss the inconsistency of the interaction across exposure metrics, the possibility of unmeasured confounding by folate intake, and the importance of examining this association in populations with lower folate intake and/or higher exposure to air pollution.