In situ high-throughput study of drug polymorphism under controlled temperature and humidity using FT-IR spectroscopic imaging
In situ high-throughput study of drug polymorphism under controlled temperature and humidity using FT-IR spectroscopic imaging
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DOI：
10.1016/j.vibspec.2006.07.015
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发表时间：
2007-01-16
影响因子：
2.5
通讯作者：
Chryssikos, G. D.
中科院分区：
文献类型：
--
作者：
Chan, K. L. A.;Kazarian, S. G.;Chryssikos, G. D.
傅里叶变换红外（FT-IR）光谱成像与受控湿度池相结合，用于同时监测两种药物的几种二元混合物在相同环境下的结晶。研究了相对湿度对不同摩尔比的硝苯地平和尼群地平二元混合物样品以及无定形尼群地平样品的影响。所有样品以阵列形式排列在BaF 2窗口的表面上，用于使用红外焦平面阵列检测器同时成像。采用新的成像方法，解决了样品厚度对成像结果分析的影响。通过绘制对应于对各种结晶多晶型物的形成敏感的v（N-H）振动模式的峰最大值的波数分布来获得厚度无关图像。在这项工作中描述的FT-IR光谱成像方法可以用于在受控环境下对许多样品进行进一步的高通量研究。(C)2006 Elsevier B. V.保留所有权利。
Fourier transform infrared (FT-IR) spectroscopic imaging in combination with a controlled humidity cell was applied to simultaneously monitor crystallisation of several binary mixtures of two drugs under identical environment. The effect of relative humidity was studied on samples of binary mixtures of nifedipine and nitrendipine with different molar ratios as well as on amorphous nitrendipine. All samples were arranged in array format on the surface of BaF2 window for simultaneous imaging using an infrared focal plane array detector. The effect of sample thickness on the analysis of imaging results was addressed using novel approach to create images. The thickness-independent images have been obtained by plotting the distribution of the wavenumber corresponding to the peak maximum of the v(N-H) vibrational mode which is sensitive to the formation of the various crystalline polymorphs. The FT-IR spectroscopic imaging approach described in this work can be utilised in further high-throughput studies of many samples under controlled environment. (C) 2006 Elsevier B.V. All rights reserved.