Highly efficient dendrimer-based mimic of glutathione peroxidase.
Highly efficient dendrimer-based mimic of glutathione peroxidase.
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DOI：
10.1021/ja048890w
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发表时间：
2004-08
影响因子：
15
通讯作者：
Xi Zhang;Huaping Xu;Z. Dong;Yapei Wang;Junqiu Liu;Jia-cong Shen
中科院分区：
文献类型：
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作者：
Xi Zhang;Huaping Xu;Z. Dong;Yapei Wang;Junqiu Liu;Jia-cong Shen
在这篇通讯中，我们报道了三代Fréchet型聚芳醚树枝状大分子的合成，这些树枝状大分子具有代际依赖的谷胱甘肽过氧化物酶活性，第三代产品的初始还原速率高达2431.20微米-1，比ebselen快约1400倍。它代表了一个使用树枝状大分子作为GPX模拟模型的成功例子。
In this communication, we report the synthesis of the three generations of Fréchet-type poly(aryl ether) dendrimers with a diselenide core that demonstrate generation-dependent glutathione peroxidase (GPx) activity with initial reduction rates as high as 2431.20 muM min-1 for the third-generation product, around 1400 times faster than Ebselen. It represents a successful example of using a dendrimer as a model for a GPx mimic.