Proton Magnetic Resonance Spectroscopy in Adults with Childhood Lead Exposure
Proton Magnetic Resonance Spectroscopy in Adults with Childhood Lead Exposure
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DOI：
10.1289/ehp.1002176
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发表时间：
2011-03-01
影响因子：
10.4
通讯作者：
Lanphear, Bruce P.
中科院分区：
文献类型：
--
作者：
Cecil, Kim M.;Dietrich, Kim N.;Lanphear, Bruce P.
背景：儿童期铅暴露对神经发育有不良影响。然而，很少有研究探讨了人类大脑代谢的变化，这可能是已知的不良认知和行为outcome.Objective：我们研究了平均儿童血铅水平和体内脑代谢物浓度之间的关联，通过质子磁共振波谱（MRS）确定在一个出生队列记录低至中度铅暴露。来自辛辛那提电极导线研究的成人参与者[n = 159;平均年龄（+/- SD），20.8 +/- 0.9岁]完成了定量、短回波质子MRS方案，评价7个区域以确定N-乙酰天冬氨酸（NAA）、肌酸和磷酸肌酸（Cr）的脑浓度，胆碱（Cho）、肌醇以及谷氨酸和谷氨酰胺的复合物（GLX）。相关性和多元线性回归分析carried.RESULTS：平均儿童血铅水平与区域特定的脑代谢物浓度调整年龄在成像和全面智商。单位估计的调整后分析（微克/分升）平均儿童血铅浓度增加，基底神经节NAA和Cr浓度水平降低，小脑半球NAA和Cho浓度水平降低，小脑蚓部GLX浓度水平降低，顶叶白色物质Cho和GLX浓度水平降低，和减少的Cho浓度水平在额叶白色matter.CONCLUSIONS：灰质NAA减少与儿童血铅水平的增加表明，持续的儿童期铅暴露产生不可逆的模式的神经元功能障碍，而相关的白质胆碱下降表明髓鞘结构的永久性改变。
BACKGROUND: Childhood lead exposure adversely affects neurodevelopment. However, few studies have examined changes in human brain metabolism that may underlie known adverse cognitive and behavioral outcomes.OBJECTIVE: We examined the association between mean childhood blood lead levels and in vivo brain metabolite concentrations as adults, determined by proton magnetic resonance spectroscopy (MRS) in a birth cohort with documented low-to-moderate lead exposure.METHODS: Adult participants from the Cincinnati Lead Study [n = 159; mean age (+/- SD), 20.8 +/- 0.9 years] completed a quantitative, short-echo proton MRS protocol evaluating seven regions to determine brain concentrations of N-acetyl aspartate (NAA), creatine and phosphocreatine (Cr), cholines (Cho), myo-inositol, and a composite of glutamate and glutamine (GLX). Correlation and multiple linear regression analyses were conducted.RESULTS: Mean childhood blood lead levels were associated with regionally specific brain metabolite concentrations adjusted for age at imaging and Full-Scale intelligence quotient. Adjusted analyses estimated for a unit (micrograms per deciliter) increase in mean childhood blood lead concentrations, a decrease of NAA and Cr concentration levels in the basal ganglia, a decrease of NAA and a decrease of Cho concentration levels in the cerebellar hemisphere, a decrease of GLX concentration levels in vermis, a decrease of Cho and a decrease of GLX concentration levels in parietal white matter, and a decrease of Cho concentration levels in frontal white matter.CONCLUSIONS: Gray-matter NAA reductions associated with increasing childhood blood lead levels suggest that sustained childhood lead exposure produces an irreversible pattern of neuronal dysfunction, whereas associated white-matter choline declines indicate a permanent alteration to myelin architecture.