Ras proteins: paradigms for compartmentalised and isoform-specific signalling.
Ras proteins: paradigms for compartmentalised and isoform-specific signalling.
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DOI：
10.1007/s00018-007-7133-8
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发表时间：
2007-10
影响因子：
8
通讯作者：
Prior, I. A.
中科院分区：
文献类型：
--
作者：
Omerovic, J.;Laude, A. J.;Prior, I. A.
Ras gtpase通过将大量细胞外刺激转化为特定的生物反应，包括增殖、分化和生存，介导多种细胞过程。在哺乳动物细胞中，三个ras基因编码四种ras亚型（H-Ras、K-Ras4A、K-Ras4B和N-Ras），它们高度同源，但功能不同。两种异构体之间的差异，包括它们的翻译后修饰和细胞内分选，意味着Ras已成为区隔化信号和膜生物学的重要模型系统。不同亚细胞位置的Ras亚型被认为可以招募不同的上游和下游辅助蛋白并激活多种信号通路。在这里，我们总结了与异构体特异性信号传导相关的数据，它在疾病中的作用和促进区隔信号传导的机制。对这一领域的进一步了解将揭示Ras信号在发育、细胞稳态和癌症中的作用，并可能提出新的治疗方法。
Ras GTPases mediate a wide variety of cellular processes by converting a multitude of extracellular stimuli into specific biological responses including proliferation, differentiation and survival. In mammalian cells, three ras genes encode four Ras isoforms (H-Ras, K-Ras4A, K-Ras4B and N-Ras) that are highly homologous but functionally distinct. Differences between the isoforms, including their post-translational modifications and intracellular sorting, mean that Ras has emerged as an important model system of compartmentalised signalling and membrane biology. Ras isoforms in different subcellular locations are proposed to recruit distinct upstream and downstream accessory proteins and activate multiple signalling pathways. Here, we summarise data relating to isoform specific signalling, its role in disease and the mechanisms promoting compartmentalised signalling. Further understanding of this field will reveal the role of Ras signalling in development, cellular homeostasis and cancers and may suggest new therapeutic approaches.
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影响因子：
5.3
作者：
Apolloni, A;Prior, IA;Hancock, JF
通讯作者：
Hancock, JF
影响因子：
64.8
作者：
Daniels, Mark A.;Teixeiro, Emma;Palmer, Ed
通讯作者：
Palmer, Ed
影响因子：
4.8
作者：
Clyde-Smith, J;Silins, G;Hancock, JF
通讯作者：
Hancock, JF
影响因子：
4.8
作者：
Baker, TL;Zheng, H;Buss, JE
通讯作者：
Buss, JE
影响因子：
7.7
作者：
Augsten, M;Pusch, R;Rubio, I
通讯作者：
Rubio, I