Effects of chicken-liver hydrolysates on lipid metabolism in a high-fat diet
Effects of chicken-liver hydrolysates on lipid metabolism in a high-fat diet
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DOI：
10.1016/j.foodchem.2014.03.052
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发表时间：
2014-10-01
期刊：
影响因子：
8.8
通讯作者：
Chen, Yi-Chen
中科院分区：
文献类型：
--
作者：
Yang, Kou-Tai;Lin, Chen;Chen, Yi-Chen
胃酶水解鸡肝脏后，游离疏水氨基酸、牛磺酸和肌肽/鹅丝氨酸的含量均升高，与干鸡肝相比，差异有统计学意义。鸡肝水解物(CLHs)具有体外抑制脂肪酶活性和胆汁酸结合能力(p<；0.05)。将48只雄性仓鼠随机分为四组：(1)饲喂高脂饲料；(2)高脂饲料；(3)高脂饲料+100 mg/kgbw；(4)高脂饲料+200 mg/kgbw；(5)高脂饲料+400 mg/kgbw；(6)高脂饲料+200 mg肌肽/kgbw。高脂饲料组小鼠血清氧化应激减轻(p<；0.05)，血脂谱改善(p<；0.05)，抗氧化能力提高(p<；0.05)，肝脏脂质积聚、氧化应激及肝组织中肿瘤坏死因子-α/白介素1-β水平降低(p<；0.05)。这些益处可能源于调节脂质平衡和增加粪便胆汁酸的产量(p<；0.05)。由此可见，在高脂饮食习惯下，CLHs具有与纯肌肽相似的脂质稳态和抗氧化能力。(C)2014爱思唯尔有限公司。保留所有权利。
The contents of free hydrophobic amino acids, taurine and carnosine/anserine were elevated after hydrolyzing chicken livers by pepsin and compared to dried chicken livers. Chicken-liver-hydrolysates (CLHs) exhibited in vitro inhibitory lipase activity and bile-acid binding ability (p < 0.05). Forty-eight male hamsters were assigned randomly to the following groups: (1) chow diet; (2) high-fat diet (HFD); (3) HFD and 100 mg CLH/kg BW; (4) HFD and 200 mg CLH/kg BW; (5) HFD and 400 mg CLH/kg BW; (6) HFD and 200 mg carnosine/kg BW. CLHs alleviated (p < 0.05) serum oxidative stress and improved (p < 0.05) the serum lipid profile in the high-fat dietary groups; meanwhile, improved (p < 0.05) antioxidant abilities and decreased (p < 0.05) lipid accumulation, oxidative stress and TNF-alpha/IL-1 beta levels in the livers. These benefits might result from regulations of lipid homeostasis and increased faecal bile-acid outputs (p < 0.05). Hence, lipid-homeostasis and antioxidant abilities of CLHs in the high-fat dietary habit were demonstrated and were similar to pure carnosine. (C) 2014 Elsevier Ltd. All rights reserved.