Protective Effects of Ophiocordyceps lanpingensis on Glycerol-Induced Acute Renal Failure in Mice.
Protective Effects of Ophiocordyceps lanpingensis on Glycerol-Induced Acute Renal Failure in Mice.
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DOI：
10.1155/2017/2012585
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发表时间：
2017
影响因子：
4.1
通讯作者：
Ge F
中科院分区：
文献类型：
--
作者：
Zhang Y;Du Y;Yu H;Zhou Y;Ge F
氧化应激和免疫反应与急性肾衰竭（ARF）有关。兰平冬虫夏草 (OL) 可能是一种抗氧化剂和免疫增强剂。在这项研究中，我们探讨了 OL 对甘油诱导的 ARF 的保护作用。 将雄性小鼠随机分为四组，即甘油诱导的ARF模型组、低剂量OL治疗组（1.0g/kg/d）、高剂量OL治疗组（2.0g/kg/d）和对照组。使用肾脏指数、血清肌酐（Cr）、血尿素氮（BUN）和组织学分析评估肾脏状况。使用肌酸激酶（CK）水平监测横纹肌溶解症。使用肾组织谷胱甘肽 (GSH)、丙二醛 (MDA) 和超氧化物歧化酶 (SOD) 水平测定氧化应激。使用免疫器官指数和免疫球蛋白 G (IgG) 水平评估免疫状态。 OL可减轻肾脏病理损伤，降低肾脏指数、血清Cr、CK、BUN、MDA的异常水平，升高免疫器官指数及IgG、GSH、SOD的水平。高剂量 OL 治疗对 ARF 的治疗效果比低剂量 OL 更积极。 OL 可以通过抑制氧化应激和增强免疫反应来改善甘油诱导的 ARF 小鼠的肾功能障碍。
Oxidative stress and immune response are associated with acute renal failure (ARF). Ophiocordyceps lanpingensis (OL) might be an antioxidant and immunopotentiator. In this study, we explored the protective effects of OL on glycerol-induced ARF. Male mice were randomly divided into four groups, specifically, glycerol-induced ARF model group, low-dose OL-treated group (1.0 g/kg/d), high-dose OL-treated group (2.0 g/kg/d), and control group. Renal conditions were evaluated using kidney index, serum creatinine (Cr), blood urea nitrogen (BUN), and histological analysis. Rhabdomyolysis was monitored using creatine kinase (CK) level. Oxidative stress was determined using kidney tissue glutathione (GSH), malondialdehyde (MDA), and superoxide dismutase (SOD) levels. Immune status was evaluated using immune organ indices and immunoglobulin G (IgG) level. OL could relieve renal pathological injury and decrease the abnormal levels of kidney index, serum Cr, CK, BUN, and MDA, as well as increase the immune organ indices and the levels of IgG, GSH, and SOD. Treatment with a high dose of OL had more positive therapeutic effects on ARF than using a low dose of OL. OL could ameliorate renal dysfunction in glycerol-induced ARF in mice by inhibiting oxidative stress and enhancing immune response.
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影响因子：
4.6
作者：
Nishida K;Watanabe H;Ogaki S;Kodama A;Tanaka R;Imafuku T;Ishima Y;Chuang VT;Toyoda M;Kondoh M;Wu Q;Fukagawa M;Otagiri M;Maruyama T
通讯作者：
Maruyama T
影响因子：
6.7
作者：
Chen, Zi-Hong;Dai, Yong-Dong;Zeng, Wen-Bo
通讯作者：
Zeng, Wen-Bo
模式识别受体 Mincle 对于维持急性肾脏炎症中的 M1 巨噬细胞表型至关重要
影响因子：
19.6
作者：
Lv, Lin L.;Tang, Patrick Ming-Kuen;Lan, Hui-Yao
通讯作者：
Lan, Hui-Yao
影响因子：
4.1
作者：
Cicciarelli, James C.;Lemp, Nathan A.;Shah, Tariq
通讯作者：
Shah, Tariq
影响因子：
6.1
作者：
Song, Jingjing;Wang, Yingwu;Wang, Di
通讯作者：
Wang, Di