Expression of prokineticin-receptor2(PK-R2) is a new prognostic factor in human colorectal cancer.
Expression of prokineticin-receptor2(PK-R2) is a new prognostic factor in human colorectal cancer.
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DOI：
10.18632/oncotarget.5565
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发表时间：
2015-10-13
期刊：
影响因子：
--
通讯作者：
Yamaguchi A
中科院分区：
文献类型：
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作者：
Goi T;Kurebayashi H;Ueda Y;Naruse T;Nakazawa T;Koneri K;Hirono Y;Katayama K;Yamaguchi A
结肠直肠癌细胞的侵袭性增加对于向周围器官的进展和转移是重要的。近年来的分子生物学研究表明，跨膜前动力素受体2（PK-R2）可能参与肿瘤细胞的侵袭能力。然而，没有研究评估PK-R2表达，癌症侵袭/转移的能力，以及切除的结直肠癌患者预后之间的关系。因此，我们在本研究中研究了这些因素。采用免疫组织化学方法检测324例结直肠癌患者原发灶及癌旁正常大肠黏膜中PK-R2的表达。此外，我们进行了临床病理检查和分析病人的病例与Kaplan-Meier方法。此外，使用Cox比例风险模型进行多变量分析。324例大肠癌中147例（45.3%）原发灶细胞膜上有PK-R2表达。PK-R2表达与血管浸润、淋巴结转移、肝转移和血行转移的发生率较高相关。此外，PK-R2表达的普遍性随着肿瘤分期的增加而增加。在III期根治性切除病例中，复发是最严重的问题，与无PK-R2表达的病例相比，表达PK-R2的病例的5年生存率显著降低（82.1%对66.8%），复发率较高。在预后的多因素分析中，PK-R2表达是一个独立的因素（比率2.621）。PK-R2的表达可能是大肠癌新的预后指标之一。
The increased invasiveness of colorectal cancer cells is important for progression and metastasis to the surrounding organs. According to recent molecular biological studies, signaling through transmembrane Prokineticin-Receptor2(PK-R2) is likely involved in the ability of tumor cell to invade. However, no studies have evaluated the relationship between PK-R2 expression, ability of cancer to invade/metastasize, and patient prognosis in cases of resected colorectal cancer. Accordingly, we have examined these factors in the present study. Immunohistochemical staining was performed to detect PK-R2 in the primary lesion and adjacent normal large intestine mucosa of 324 colorectal cancer patients who underwent resection surgery at our department. Additionally, we conducted clinicopathologic examinations and analyzed patient prognoses with the Kaplan-Meier method. Further, multivariate analysis was conducted using a cox-proportional hazard model. PK-R2 expression was observed on the cellular membrane of the primary lesion in 147 of 324 cases (45.3%) of human colorectal cancer. PK-R2 expression was associated with a higher incidence of vascular invasion, lymph node metastasis, hepatic metastasis, and hematogenous metastasis. Further, prevalence of PK-R2 expression increased as tumor stage increased. In stage III curative resection cases, where recurrence is the most serious problem, cases that expressed PK-R2 had a significantly lower 5-year survival rate (82.1% versus 66.8%) and higher recurrence compared to those cases with no PK-R2 expression. In the multivariate analysis for prognosis, PK-R2 expression was found to be an independent factor(ratio2.621). PK-R2 expression could be one of the new prognostic factors in human colorectal cancer.