The temporal response of the brain after eating revealed by functional MRI
The temporal response of the brain after eating revealed by functional MRI
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DOI：
10.1038/35016590
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发表时间：
2000-06-29
期刊：
影响因子：
64.8
通讯作者：
Fox, PT
中科院分区：
文献类型：
--
作者：
Liu, YJ;Gao, JH;Fox, PT
在进食后，人类的大脑会感觉到一种生化变化，然后发出饱足的信号，但这种变化发生的确切时间是未知的。即使对于葡萄糖-胰岛素调节等成熟的生理系统，激素过程和神经事件之间的相互作用的时间主要是从血液采样中推断的（1-6）。最近，神经影像学研究提供了关于能量摄入调节的神经解剖学相关性的体内信息（7-10）。然而，这些系统的时间编排对于控制进食行为的神经元和激素信号的整合至关重要（11）。这项功能性磁共振成像研究的挑战是不仅要绘制大脑在食物摄入后的反应位置，还要绘制大脑在食物摄入后的反应时间。在这里，我们使用时间聚类分析技术来证明，进食相关的神经活动在两个不同的时间与不同的定位峰值。重要的是，分化的反应与内部信号，血浆胰岛素相互作用。这些结果支持大脑活动的时间分割的概念（12），这反映了刺激和反应的不同性质。此外，这项研究为检测动态过程提供了神经成像基础，而无需事先了解其时间，例如药物和营养对大脑的急性影响。
After eating, the human brain senses a biochemical change and then signals satiation, but precisely when this occurs is unknown. Even for well-established physiological systems like glucose-insulin regulation, the timing of interaction between hormonal processes and neural events is inferred mostly from blood sampling(1-6). Recently, neuroimaging studies have provided in vivo information about the neuroanatomical correlates of the regulation of energy intake(7-10). Temporal orchestration of such systems, however, is crucial to the integration of neuronal and hormonal signals that control eating behaviour(11). The challenge of this functional magnetic resonance imaging study is to map not only where but also when the brain will respond after food ingestion. Here we use a temporal clustering analysis technique to demonstrate that eating-related neural activity peaks at two different times with distinct localization. Importantly, the differentiated responses are interacting with an internal signal, the plasma insulin. These results support the concept of temporal parcellation of brain activity(12), which reflects the different natures of stimuli and responses. Moreover, this study provides a neuroimaging basis for detecting dynamic processes without prior knowledge of their timing, such as the acute effects of medication and nutrition in the brain.