Progress in understanding the pathogenesis of the anemia of chronic disease.
Progress in understanding the pathogenesis of the anemia of chronic disease.
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DOI：
10.1182/blood.v80.7.1639.bloodjournal8071639
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发表时间：
1992-10
期刊：
影响因子：
20.3
通讯作者：
R. Means;Sanford E. Krantz
中科院分区：
文献类型：
--
作者：
R. Means;Sanford E. Krantz
对炎症反应的进一步了解，对所涉及的特定细胞因子的鉴定和表征，以及对红细胞生成的进一步了解，以及重组人生长因子如EPO的可用性，通过允许开发许多用于研究这种综合征的信息模型，大大增强了我们对ACD发病机制的认识。从红系祖细胞和EPO产生的抑制到铁释放的损伤，似乎多种细胞因子参与ACD发病机制的各个方面。这些细胞因子中的一些对ACD发展的贡献的示意图显示在图6中。这些影响发生的确切生化机制仍有待确定。本报告中概述的进展使我们能够更准确地了解这种常见且重要的临床综合征的发病机制。1983年，汉森给ACD的一篇评论起了副标题“一袋未解决的问题。虽然这种描述仍然是准确的，但我们对ACD的理解现在已经发展到我们可以提供一个更明确的副标题：“一袋细胞因子”。"
Improved understanding of the inflammatory response and the identification and characterization of the specific cytokines involved, as well as improved understanding of erythropoiesis, and the availability of recombinant human growth factors such as EPO, have greatly enhanced our appreciation of the pathogenesis of ACD by allowing development of a number of informative models for studying this syndrome. It appears that a variety of cytokines are involved in all aspects of the pathogenesis of ACD, from the inhibition of erythroid progenitors and EPO production to impairment of iron release. A schematic of the contributions of some of these cytokines to the development of ACD is shown in Fig 6. The exact biochemical mechanisms by which these effects occur is still to be determined. The progress outlined in this report has allowed us to develop a more precise understanding of the pathogenesis of this common and important clinical syndrome. In 1983, Hansen subtitled a review of ACD "A Bag of Unsolved Questions." Although this description is still accurate, our understanding of ACD has now developed to the point where we can offer a more defined subtitle: "A Bag of Cytokines."