Role of hypoxia-induced exosomes in tumor biology.
Role of hypoxia-induced exosomes in tumor biology.
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DOI：
10.1186/s12943-018-0869-y
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发表时间：
2018-08-11
期刊：
影响因子：
37.3
通讯作者：
Shen H
中科院分区：
文献类型：
--
作者：
Shao C;Yang F;Miao S;Liu W;Wang C;Shu Y;Shen H
缺氧是血管生成的主要调节因子，并且总是影响各种类型肿瘤中外泌体的释放。本文就低氧诱导的外泌体在肿瘤生物学中的作用作一综述。使用缺氧、外泌体、细胞外囊泡、肿瘤、癌症和其他类似术语等关键词从PubMed检索相关出版物。最近的研究表明，在低氧条件下，癌细胞比在常氧条件下的亲本细胞产生更多的外泌体。在各种类型的癌症中，缺氧可影响外泌体的分泌和功能。低氧诱导的外泌体在肿瘤血管生成、侵袭、转移和免疫系统中起关键作用。这些发现为细胞和基因组调控响应缺氧的复杂网络提供了新的见解，并可能为未来的治疗提供新的和特定的靶点。
Hypoxia is a major regulator of angiogenesis and always influences the release of exosomes in various types of tumors. The present review aimed to assess the role of hypoxia-induced exosomes in the tumor biology. The relevant publications were retrieved from PubMed using keywords such as hypoxia, exosome, extracellular vesicles, tumor, cancer, and other similar terms. Recent studies have shown that cancer cells produce more exosomes under hypoxic conditions than do parental cells under normoxic conditions. The secretion and function of exosomes could be influenced by hypoxia in various types of cancer. Hypoxia-induced exosomes play critical roles in tumor angiogenesis, invasion, metastasis, and the immune system. These findings provide new insights into the complex networks underlying cellular and genomic regulation in response to hypoxia and might provide novel and specific targets for future therapies.
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