Association of Human Papillomavirus Infection With Cervical Intraepithelial Neoplasia
Association of Human Papillomavirus Infection With Cervical Intraepithelial Neoplasia
复制标题
人乳头瘤病毒感染与宫颈上皮内瘤变的关联
作者：
A. Grunebaum;A. Sedlis;F. Sillman;R. Fruchter;A. Stanek;J. Boyce
在阴道镜诊所就诊的患者中评估了宫颈人乳头瘤病毒感染情况。在 348 名宫颈活检患者中，134 名（38.5%）人乳头瘤病毒感染，251 名宫颈上皮内瘤变（CIN）患者中 112 名（44.6%）人乳头瘤病毒感染。大多数人乳头瘤病毒患者并发 CIN（83.6%；112/134）。感染人乳头瘤病毒的患者明显比未感染人乳头瘤病毒的患者年轻（平均年龄分别为 24.4 岁与 29.9 岁；P < .001），CIN 程度明显较轻（轻度/中度不典型增生为 84% 与 43%；P <.001），并且平均妊娠次数显着较低（2.16 岁与 3.05 岁；P <.001）。 69 对配对分析显示，人乳头瘤病毒和非人乳头瘤病毒患者的 CIN 分布相同。人乳头瘤病毒特异性挖空细胞的电子显微镜证实细胞核中存在人乳头瘤病毒颗粒。
Human papillomavirus infections of the cervix were assessed in patients attending a colposcopy clinic. Of 348 patients with cervical biopsies, 134 (38.5%) had human papillomavirus infections, and of 251 patients with cervical intraepithelial neoplasia (CIN) 112 (44.6%) had human papillomavirus. The majority of patients with human papillomavirus had concurrent CIN (83.6%; 112/134). Patients with human papillomavirus were significantly younger than patients without human papillomavirus (24.4 versus 29.9 years mean age; P < .001), had significantly milder degrees of CIN (84% versus 43% mild/moderate dysplasia; P < .001), and had a significantly lower mean number of pregnancies (2.16 versus 3.05; P <.001). A matched pairs analysis of 69 pairs showed the same distribution of CIN in both human papillomavirus and nonhuman papillomavirus patients. Electron microscopy of human papillomavirus-specific koilocytes confirmed the presence of human papillomavirus particles in the nuclei.