Uric Acid and Left Ventricular Hypertrophy in Japanese Men
Uric Acid and Left Ventricular Hypertrophy in Japanese Men
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DOI：
10.1253/circj.cj-08-0626
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发表时间：
2009-04-01
影响因子：
3.3
通讯作者：
Tarnakoshi, Koji
中科院分区：
文献类型：
--
作者：
Mitsuhashi, Hirotsugu;Yatsuya, Hiroshi;Tarnakoshi, Koji
背景：实验研究表明，别嘌呤醇可以保护高血压大鼠免受左心室肥厚 (LVH) 的影响，而对血压 (BP) 的影响可以忽略不计。尿酸（UA）被认为可部分通过激活肾素-血管紧张素系统来诱导心肌细胞生长和心脏间质纤维化。在本研究中，在未服用高血压药物 (HTN) 的日本男性中检查了血清 UA 水平与心电图诊断的 LVH (ECG-LVH) 之间的关系，这可能会混淆这种关联。方法和结果：总共对 3,305 名年龄 35-66 岁的男性工人（平均年龄 +/- SD，48.0 +/- 7.1）进行了研究。 LVH 被定义为满足 ECG 标准（即 Sokolow-Lyon 电压和/或 Cornell 电压 QRS 持续时间乘积）。根据血清UA水平的三分位数将受试者分为3组。与最低三分位数相比，最高三分位数（UA 范围 0.39-0.65mmol/L 或 6.6-11.0 mg/dl）的 LVH 患病率显着增加，与年龄、体重指数、血清肌酐水平、高血压、糖尿病和高脂血症无关（比值比 1.58，95% 置信区间 1.23-2.02，P
Background: Experimental studies have reported that allopurinol protects hypertensive rats from left ventricular hypertrophy (LVH) with negligible effects on blood pressure (BP). Uric acid (UA) was thought to induce cardiomyocyte growth and interstitial fibrosis of the heart, partly via activation of the renin-angiotensin system. In the present study, the relationship between serum UA levels and electrocardiographically-diagnosed LVH (ECG-LVH) was examined in Japanese men not taking medication for hypertension (HTN), which could confound the association.Methods and Results: A total of 3,305 male workers aged 35-66 years (mean age +/- SD, 48.0 +/- 7.1) were studied. LVH was defined as meeting the ECG criteria (ie, Sokolow-Lyon voltage and/or Cornell voltage QRS duration product). Subjects were divided into 3 groups by tertile of serum UA level. The highest tertile (UA range 0.39-0.65mmol/L or 6.6-11.0 mg/dl) had a significantly increased prevalence of LVH compared with the lowest tertile independent of age, body mass index, serum creatinine level, HTN, diabetes and hyperlipidemia (odds ratio 1.58, 95% confidence interval 1.23-2.02, P