Physiology and morphology of inverted pyramidal neurons in the rodent neocortex.
Physiology and morphology of inverted pyramidal neurons in the rodent neocortex.
复制标题
啮齿动物新皮质倒锥体神经元的生理学和形态学。
DOI：
10.1016/j.neuroscience.2013.06.004
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发表时间：
2013
期刊：
影响因子：
3.3
通讯作者：
Brumberg,JC
中科院分区：
文献类型：
--
作者：
Steger,RM;Ramos,RL;Cao,R;Yang,Q;Chen,C-C;Dominici,J;Brumberg,JC
越来越多的研究表明，存在更大的多样性皮层神经元比以前认识到的。在本报告中，我们使用的生理和形态学方法相结合的特点，在颗粒下层的皮质神经元与顶树突指向白质相比，那些神经元与顶树突指向软脑膜在小鼠和大鼠新皮质。这些“倒置”神经元的树突形态和内在和突触生理学的几个特征揭示了这种细胞类型在物种之间的许多差异。我们还发现了同一物种中不同细胞类型之间的差异。这些数据表明，大鼠和小鼠中相似的细胞类型可能并不总是具有相似的生理和形态学特性。这些数据是相关的信息处理模型，通过微观和更大的新皮层电路，并表明，不同的细胞类型中发现类似的椎板可以有不同的功能特性。
An increasing number of studies indicate that there exists greater diversity of cortical neurons than previously appreciated. In the present report, we use a combination of physiological and morphological methods to characterize cortical neurons in infragranular layers with apical dendrites pointing toward the white-matter compared to those neurons with apical dendrites pointing toward the pia in both mouse and rat neocortex. Several features of the dendritic morphology and intrinsic and synaptic physiology of these “inverted” neurons revealed numerous differences among this cell type between species. We also found differences between the different cell types within the same species. These data reveal that similar cell types in the rat and mouse may not always share similar physiological and morphological properties. These data are relevant to models of information processing through micro- and larger neocortical circuits and indicate that different cell types found within similar lamina can have different functional properties.