Dysfunction of ionic channels in cardiomyocyte sarcolemma and cardiac arrhythmias
Dysfunction of ionic channels in cardiomyocyte sarcolemma and cardiac arrhythmias
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DOI：
10.1007/s10517-006-0181-5
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发表时间：
2006-04-01
影响因子：
0.7
通讯作者：
Lipnitskii, T. N.
中科院分区：
文献类型：
--
作者：
Moroz, V. M.;Lipnitskii, T. N.
本文观察了乌头碱诱发大鼠心律失常时细胞内Na ~+、Ca ~（2+）失衡的药理作用。在Na+依赖性心律失常的情况下，维拉帕米阻断Ca 2+通道可加重心律失常。静脉注射钙制剂纠正乌头碱所致心律失常的离子失衡，促进稳定窦性心律的恢复，降低动物死亡率。细胞内Na+和Ca 2+离子的失衡可能是抗肿瘤药物致肿瘤作用的基础。
The arrhythmic effects of Na+ and Ca2+ intracellular imbalance were examined on rats with aconitine-induced cardiac arrhythmias. Under conditions of Na+-dependent arrhythmogenesis, blockade of Ca2+-channels with verapamil aggravated cardiac rhythm disturbances. Correction of ionic imbalance by intravenous injection of calcium preparations in aconitine-induced arrhythmia promoted recovery of stable sinus rhythm and decreased animal mortality. Intracellular imbalance of Na+ and Ca2+ ions can underlie the arrhythmogenic effects of antiarrhythmic drugs.