Surgical resection of hepatic and rectal metastases of pancreatic acinar cell carcinoma (PACC): a case report.
Surgical resection of hepatic and rectal metastases of pancreatic acinar cell carcinoma (PACC): a case report.
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DOI：
10.1186/s12957-018-1457-8
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发表时间：
2018-08-03
影响因子：
3.2
通讯作者：
Ohkohchi N
中科院分区：
文献类型：
--
作者：
Ohara Y;Oda T;Enomoto T;Hisakura K;Akashi Y;Ogawa K;Owada Y;Domoto Y;Miyazaki Y;Shimomura O;Kurata M;Ohkohchi N
胰腺腺泡细胞癌（PACC）是一种罕见的胰腺恶性肿瘤，其治疗方法通常与胰腺导管腺癌（PDAC）相同。手术切除是治愈的途径；然而，一旦转移（通常转移到肝、肺、淋巴结或腹腔），全身化疗是唯一的选择，但结果不利。67岁男性，因胰尾恶性肿瘤累及整个胰腺，出现食欲不振和体重下降的症状。全胰切除术后病理诊断为PACC。胰切除术后24个月，单发肝转移患者行部分肝切除术，4个月后，患者出现黑黑。进一步检查显示为2型直肠肿瘤。活检后病理检查为PACC直肠转移，行腹会阴切除治疗。随后，患者在胰腺切除术后40个月未出现肿瘤复发。这是一个罕见的病例PACC表现为肝和直肠的异位转移，我们成功地通过手术切除治疗他们。由于PACC的恶性行为通常小于PDAC，因此即使在转移灶数量和范围有限的情况下，手术切除也是一种选择。
Pancreatic acinar cell carcinoma (PACC), a rare variant of pancreatic malignancy, is generally managed the same way as pancreatic ductal adenocarcinoma (PDAC). Surgical resection is the gateway to curing it; however, once it metastasizes (usually to the liver, lungs, lymph nodes, or peritoneal cavity), systemic chemotherapy has been the only option, but with unfavorable results. A 67-year-old man with symptoms of loss of appetite and weight underwent surgery for malignancy of the pancreatic tail extending into the entire pancreas. The pathological diagnosis was PACC following total pancreatectomy. Twenty-four months after the pancreatectomy, a solitary liver metastasis was treated by partial hepatectomy, and, subsequently, 4 months later, he presented with melena. Further examination revealed a type-2 rectal tumor. Histological examination following biopsy revealed it to be rectal metastasis of PACC, and it was treated by abdominoperineal resection. Subsequently, the patient did not have tumor recurrence as of 40 months after pancreatectomy. This is a rare case of PACC presenting with metachronal metastases in the liver and rectum, and we successfully treated them by surgical resections. Since the malignant behavior of PACC is usually less than that of PDAC, surgical resection could be an option even for metastatic lesions when the number and extent of metastases are limited.
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影响因子：
45.3
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通讯作者：
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