Motor memory preservation in aged monkeys mirrors that of aged humans on a similar task
Motor memory preservation in aged monkeys mirrors that of aged humans on a similar task
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DOI：
10.1016/j.neurobiolaging.2007.03.016
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发表时间：
2008-10-01
影响因子：
4.2
通讯作者：
Grondin, Richard
中科院分区：
文献类型：
--
作者：
Walton, Ashley;Scheib, Jami L.;Grondin, Richard
我们研究了恒河猴的长期运动记忆保存，测试了与人类相似的任务。首先，测量了 23 只 4 岁至 26 岁动物的运动速度和运动衰退率。动物的任务包括从自动面板内室内的弯曲杆上取出食物奖励。年轻动物的表现是年老动物的两倍。第二。一年后，年轻的（n = 6）和年老的（n = 10）动物被重新测试相同的任务，没有任何干预练习。我们预计老年动物的运动速度将下降 144 毫秒/年，但重复训练期间记录的平均表现时间却显着提高了 17%。这一发现反映了一项使用类似测试组在人类中进行的纵向研究，并支持这样的观点：虽然一项新的运动任务的初始执行时间随着年龄的增长而下降，但运动记忆痕迹在整个较长的时间间隔内得以保留，即使没有继续练习。该数据还支持恒河猴可以作为模型来研究衰老过程中运动记忆长期保留的机制 (C) 2007 Elsevier Inc. 保留所有权利。
We Studied long-term motor memory preservation in rhesus monkeys tested oil a task similar to that employed in humans. First, motor speed and rate of motor decline was measured in 23 animals ranging from 4 to 26 years old. The task for the animals consisted of removing a food reward from a curved rod within the inner chamber of an automated panel. Young animals performed twice as fast as the aged animals. Second. young (n = 6) and aged (n = 10) animals were re-lested I year later oil the same task with no intervening practice. We anticipated a decline in motor speed of 144 ms/year., instead the average performance time recorded during the repeat session improved significantly by 17% in the aged animals. This finding mirrors that of a longitudinal Study conducted in humans using a similar test panel and supports that, while initial performance times of a novel motor task decline with age, motor memory traces are preserved over ail extended time interval, even Without Continued practice. The data also Support that the rhesus Monkey could be used as a model to study the mechanisms by which long-term retention of motor memory Occurs in aging (C) 2007 Elsevier Inc. All rights reserved.