MR-OPERA: A Multicenter/Multivendor Validation of Magnetic Resonance Imaginge-Only Prostate Treatment Planning Using Synthetic Computed Tomography Images
MR-OPERA: A Multicenter/Multivendor Validation of Magnetic Resonance Imaginge-Only Prostate Treatment Planning Using Synthetic Computed Tomography Images
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DOI：
10.1016/j.ijrobp.2017.06.006
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发表时间：
2017-11-01
影响因子：
7
通讯作者：
Jonsson, Joakim
中科院分区：
文献类型：
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作者：
Persson, Emilia;Gustafsson, Christian;Jonsson, Joakim
目的：为了验证剂量测定的准确性和临床稳健性的商业软件的磁共振（MR）合成计算机断层扫描（sCT）转换，在MR成像的工作流程为170前列腺癌patients.Methods和材料：4个参与中心有MriPlanner（Spectronic Medical），一个基于图集的sCT生成软件，安装作为一个基于云的服务。将覆盖身体轮廓的T2加权MR序列添加到临床方案中。MR图像从MR扫描仪工作站发送到MriPlanner平台。sCT自动返回治疗计划系统。本研究包括4台MR扫描仪和2种磁场强度。对于每例患者，根据临床实践创建并批准CT治疗计划。将sCT严格配准到CT，并在sCT上重新计算临床治疗计划。根据一组剂量-体积直方图参数和伽马评价，比较CT计划和sCT计划的剂量分布。治疗技术包括体积调制弧治疗，调强放射治疗，和传统的治疗使用2个治疗计划系统和不同的剂量calculationalgorithm.Results：整体（多中心/多供应商）sCT和CT剂量分布之间的平均剂量差异低于0.3%的所有评估器官和目标。伽马评价平均通过率为99.12%全体体积为0.63%，1 SD，全体体积为99.97%（0.13%，1 SD），使用2%/ 2-mm全局伽马标准。结论：研究结果表明，sCT转换方法可用于临床，靶器官和相关危险器官的sCT和CT剂量分布之间的差异最小。观察到的微小差异在各中心之间一致，表明使用MriPlanner的仅MR成像工作流程对于各种场强、供应商和治疗技术都是稳健的。(C)2017作者（S）爱思唯尔公司出版
Purpose: To validate the dosimetric accuracy and clinical robustness of a commercially available software for magnetic resonance (MR) to synthetic computed tomography (sCT) conversion, in an MR imaginge-only workflow for 170 prostate cancer patients.Methods and Materials: The 4 participating centers had MriPlanner (Spectronic Medical), an atlas-based sCT generation software, installed as a cloud-based service. A T2-weighted MR sequence, covering the body contour, was added to the clinical protocol. The MR images were sent from the MR scanner workstation to theMriPlanner platform. The sCT was automatically returned to the treatment planning system. Four MR scanners and 2 magnetic field strengths were included in the study. For each patient, a CT-treatment plan was created and approved according to clinical practice. The sCT was rigidly registered to the CT, and the clinical treatment plan was recalculated on the sCT. The dose distributions from the CT plan and the sCT plan were compared according to a set of dose-volume histogram parameters and gamma evaluation. Treatment techniques included volumetric modulated arc therapy, intensity modulated radiation therapy, and conventional treatment using 2 treatment planning systems and different dose calculation algorithms.Results: The overall (multicenter/multivendor) mean dose differences between sCT and CT dose distributions were below 0.3% for all evaluated organs and targets. Gamma evaluation showed a mean pass rate of 99.12% (0.63%, 1 SD) in the complete body volume and 99.97% (0.13%, 1 SD) in the planning target volume using a 2%/ 2-mm global gamma criteria.Conclusions: Results of the study show that the sCT conversion method can be used clinically, with minimal differences between sCT and CT dose distributions for target and relevant organs at risk. The small differences seen are consistent between centers, indicating that an MR imagingeonly workflow using MriPlanner is robust for a variety of field strengths, vendors, and treatment techniques. (C) 2017 The Author(s). Published by Elsevier Inc.