Studies on the mechanism of lymphocyte-mediated cytolysis. IV. Specificity of the histamine receptor on effector T cells.
Studies on the mechanism of lymphocyte-mediated cytolysis. IV. Specificity of the histamine receptor on effector T cells.
复制标题
淋巴细胞介导的细胞溶解机制的研究。
作者：
M. Plaut;L. Lichtenstein;E. Gillespie;C. Henney
在免疫C57BL/6效应细胞和DBA/2肥大细胞瘤靶细胞的细胞溶解系统中，研究了组胺对胸腺来源淋巴细胞介导的细胞溶解的抑制作用。组胺以可逆的方式抑制细胞溶解，并刺激效应细胞内的环磷酸腺苷水平。组胺抑制可被布林胺特异性拮抗，但不能被其他抗组胺药物如苯海拉明所拮抗。这种拮抗作用的特异性表明，效应胸腺来源细胞上的组胺受体仅为组胺2型。
The inhibition of thymus-derived lymphocyte-mediated cytolysis by histamine has been studied in a cytolytic system with immune C57BL/6 effector cells and DBA/2 mastocytoma target cells. Histamine inhibited cytolysis in a reversible manner, and stimulated intracellular cyclic AMP levels in the effector cell. Histamine inhibition was specifically antagonized by burimamide but not by other antihistamines, such as diphenhydramine. The specificity of this antagonism suggests that the histamine receptor on effector thymus-derived cells is of the histamine 2 type only.