Characterization and Localization ofβ 2-Adrenergic Receptors in the Bovine Oviduct: Indication for Progesterone-Mediated Expression.
Characterization and Localization ofβ 2-Adrenergic Receptors in the Bovine Oviduct: Indication for Progesterone-Mediated Expression.
复制标题
牛输卵管中β 2-肾上腺素能受体的特征和定位：黄体酮介导表达的指示。
作者：
Ralf Einspanier;C. Gabler;A. Kettler;W. Kloas
通过受体结合研究和表达分析，在牛输卵管上皮中检测到β2肾上腺素能受体。互补DNA克隆得到了第一个全长牛β 2-肾上腺素受体信使RNA序列（2030个碱基）。输卵管上皮细胞中的受体生物活性的特征在于特异性配体相互作用和随之产生的cAMP。表达研究表明，动情周期依赖性调节，较高的转录水平和显着增加结合能力在黄体期。补充孕酮后，输卵管上皮细胞在培养物中显示出升高的受体表达，支持孕酮上调这些细胞内β2-肾上腺素能受体的假设。看来，来自循环或神经支配的儿茶酚胺可能能够通过调节输卵管分泌来影响生殖成功。
β2-Adrenergic receptors were detected in bovine oviductal epithelium by use of receptor binding studies and expression analysis. Complementary DNA cloning gave use to the first full-length bovineβ 2-adrenoceptor messenger RNA sequence (2030 bases). Receptor bioactivity in oviduct epithelial cells was characterized by specific ligand interaction and consequent cAMP generation. Expression studies demonstrated an estrous cycle-dependent regulation, with higher transcript levels and significantly increased binding capacity during the luteal phase. After progesterone supplementation, oviduct epithelial cells showed elevated receptor expression in culture, supporting the hypothesis that progesterone up-regulates the β2-adrenergic receptor within these cells. It seems likely that catecholamines from the circulation or from innervation might be able to influence reproductive success by regulating oviductal secretion.
CNS β 肾上腺素能受体的定位和数量的物种差异：大鼠与豚鼠。
DOI：
--
发表时间：
1989
期刊：
The Journal of pharmacology and experimental therapeutics
影响因子：
--
作者：
Booze,RM;Crisostomo,EA;Davis,JN
通讯作者：
Davis,JN
猪黄体和颗粒细胞上β-肾上腺素能受体的特性。
影响因子：
4.8
作者：
Perkins,SN;Cronin,MJ;Veldhuis,JD
通讯作者：
Veldhuis,JD
雌激素降低兔子宫肌层中 β-肾上腺素受体介导的 cAMP 产生和鸟苷酸调节蛋白 Gs 的浓度。
影响因子：
3.6
作者：
Riemer,RK;Wu,YY;Bottari,SP;Jacobs,MM;Goldfien,A;Roberts,JM
通讯作者：
Roberts,JM