Targeting the LKB1 tumor suppressor.
Targeting the LKB1 tumor suppressor.
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DOI：
10.2174/1389450114666140106095811
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发表时间：
2014-01
影响因子：
3.2
通讯作者：
Xu ZX
中科院分区：
文献类型：
--
作者：
Zhao RX;Xu ZX
LKB 1（也称为丝氨酸-苏氨酸激酶11，STK 11）是一种肿瘤抑制因子，在Peutz-Jeghers综合征（PJS）和多种癌症中突变或缺失。在生理上，LKB 1在调节细胞生物能量代谢、细胞周期阻滞、胚胎发育、细胞极性和凋亡等方面具有多种细胞功能。新的研究表明，LKB 1也可能在维持造血干细胞的功能和动力学方面发挥作用。在过去的几年里，针对特定遗传畸变的个性化治疗引起了强烈的兴趣。在这篇评论中，几个代理商对异常LKB 1信号的潜在活动进行了讨论。潜在的战略和挑战，针对LKB 1失活也被认为是。
LKB1 (also known as serine-threonine kinase 11, STK11) is a tumor suppressor, which is mutated or deleted in Peutz-Jeghers syndrome (PJS) and in a variety of cancers. Physiologically, LKB1 possesses multiple cellular functions in the regulation of cell bioenergetics metabolism, cell cycle arrest, embryo development, cell polarity, and apoptosis. New studies demonstrated that LKB1 may also play a role in the maintenance of function and dynamics of hematopoietic stem cells. Over the past years, personalized therapy targeting specific genetic aberrations has attracted intense interests. Within this review, several agents with potential activity against aberrant LKB1 signaling have been discussed. Potential strategies and challenges in targeting LKB1 inactivation are also considered.
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影响因子：
50.3
作者：
Carretero J;Shimamura T;Rikova K;Jackson AL;Wilkerson MD;Borgman CL;Buttarazzi MS;Sanofsky BA;McNamara KL;Brandstetter KA;Walton ZE;Gu TL;Silva JC;Crosby K;Shapiro GI;Maira SM;Ji H;Castrillon DH;Kim CF;García-Echeverría C;Bardeesy N;Sharpless NE;Hayes ND;Kim WY;Engelman JA;Wong KK
通讯作者：
Wong KK
影响因子：
16
作者：
Banko, Max R.;Allen, Jasmina J.;Schaffer, Bethany E.;Wilker, Erik W.;Tsou, Peiling;White, Jamie L.;Villen, Judit;Wang, Beatrice;Kim, Sara R.;Sakamoto, Kei;Gygi, Steven P.;Cantley, Lewis C.;Yaffe, Michael B.;Shokat, Kevan M.;Brunet, Anne
通讯作者：
Brunet, Anne
影响因子：
3.9
作者：
Anisimov, VN;Berstein, LM;Franceschi, C
通讯作者：
Franceschi, C
影响因子：
11.4
作者：
Boudeau, J;Baas, AF;Alessi, DR
通讯作者：
Alessi, DR
初级纤毛通过 Lkb1 调节 mTORC1 活性和细胞大小。
影响因子：
21.3
作者：
Boehlke, Christopher;Kotsis, Fruzsina;Patel, Vishal;Braeg, Simone;Voelker, Henriette;Bredt, Saskia;Beyer, Theresa;Janusch, Heike;Hamann, Christoph;Goedel, Markus;Mueller, Klaus;Herbst, Martin;Hornung, Miriam;Doerken, Mara;Koettgen, Michael;Nitschke, Roland;Igarashi, Peter;Walz, Gerd;Kuehn, E. Wolfgang
通讯作者：
Kuehn, E. Wolfgang