Comparasite: a database for comparative study of transcriptomes of parasites defined by full-length cDNAs.
Comparasite: a database for comparative study of transcriptomes of parasites defined by full-length cDNAs.
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DOI：
10.1093/nar/gkl1039
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发表时间：
2007-01
影响因子：
14.9
通讯作者：
Sugano S
中科院分区：
文献类型：
--
作者：
Watanabe J;Wakaguri H;Sasaki M;Suzuki Y;Sugano S
Comparasite 是一个用于寄生虫转录组比较研究的数据库。在此数据库中，每个数据均由来自各种顶端复门寄生虫的全长 cDNA 定义。它集成了七个单独的数据库，Full-Parasites，由我们生成并测序的许多全长 cDNA 克隆组成：来自恶性疟原虫的 12 484 个 cDNA 序列，来自约氏疟原虫的 11 262 个 cDNA 序列，来自间日疟原虫的 9633 个 cDNA 序列，来自伯氏疟原虫的 1518 个 cDNA 序列，来自弓形虫的 7400 个 cDNA 序列。 5921 来自小隐孢子虫，10 966 来自多房棘球绦虫。假定的对应基因组被聚类，并对六个顶端复合体物种的任意组合进行比较分析，例如关于蛋白质基序（InterPro）、预测的亚细胞定位信号（PSORT）、跨膜区（SOSUI）或上游启动子元件的种间比较。通过指定关键字和其他搜索条件，Comparasite 检索包含共同或物种特异性方式的给定特征的假定对应基因组。通过对顶端复合体原生动物的基因进行多方面的比较分析，Comparasite 应该有助于阐明寄生背后的机制。顶端复体原生动物是单系生物，它们已经进化到多样化，通过采用复杂的生命周期寄生于不同的宿主。我们的全长 cDNA 数据库和 Comparasite 可从 访问。
Comparasite is a database for comparative studies of transcriptomes of parasites. In this database, each data is defined by the full-length cDNAs from various apicomplexan parasites. It integrates seven individual databases, Full-Parasites, consisting of numerous full-length cDNA clones that we have produced and sequenced: 12 484 cDNA sequences from Plasmodium falciparum, 11 262 from Plasmodium yoelii, 9633 from Plasmodium vivax, 1518 from Plasmodium berghei, 7400 from Toxoplasma gondii, 5921 from Cryptosporidium parvum and 10 966 from the tapeworm Echinococcus multilocularis. Putatively counterpart gene groups are clustered and comparative analysis of any combination of six apicomplexa species is implemented, such as interspecies comparisons regarding protein motifs (InterPro), predicted subcellular localization signals (PSORT), transmembrane regions (SOSUI) or upstream promoter elements. By specifying keywords and other search conditions, Comparasite retrieves putative counterpart gene groups containing a given feature in common or in a species-specific manner. By enabling multi-faceted comparative analyses of genes of apicomplexa protozoa, monophyletic organisms that have evolved to diversify to parasitize various hosts by adopting complex life cycles, Comparasite should help elucidate the mechanism behind parasitism. Our full-length cDNA databases and Comparasite are accessible from .