Rapid identification of Fritillariae Cirrhosae Bulbus and its adulterants by UPLC-ELSD fingerprint combined with chemometrics methods
Rapid identification of Fritillariae Cirrhosae Bulbus and its adulterants by UPLC-ELSD fingerprint combined with chemometrics methods
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DOI：
10.1016/j.bse.2017.12.007
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发表时间：
2018-02-01
影响因子：
1.6
通讯作者：
Duan, Baozhong
中科院分区：
文献类型：
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作者：
Luo, Dandan;Liu, Yuyu;Duan, Baozhong
川贝母（Fritillariae Cirrhosae Bulb，FCB）是一种著名的珍贵止咳中药，容易被意外污染、故意替代或与其他形态特征相似的物种混合。这些掺假可能会导致质量混乱和安全问题。本研究采用UPLC-ELSD指纹图谱分析技术，结合化学计量学方法，包括相似性分析、系统聚类分析和主成分分析，对FCB及其混淆品进行鉴别。结果表明，该方法能有效地鉴别和区分FCB及其掺杂物。该方法为中药的质量控制提供了一个潜在的前景。(C)2017爱思唯尔有限公司版权所有
Fritillariae Cirrhosae Bulbus (FCB) is a well-known and precious antitussive traditional Chinese medical herb. It is prone to be accidentally contaminated, deliberately substituted or admixed with other species of similar morphological characters. These adulterations might cause quality confusion and safety issues. In this study, a UPLC-ELSD fingerprint analysis with chemometric methods, including similarity analysis, hierarchical clustering analysis, and principal component analysis, were applied for the identification of FCB and its adulterants. Our results indicated that the combined method could efficiently identify and distinguish FCB from its adulterations. The proposed method provides a potential perspective for the quality control of traditional Chinese medicine. (C) 2017 Elsevier Ltd. All rights reserved.