Acute Phase Proteins In Atherosclerosis (Acute Coronary Syndrome)
Acute Phase Proteins In Atherosclerosis (Acute Coronary Syndrome)
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DOI：
10.2174/187152508785909537
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发表时间：
2008-10-01
影响因子：
--
通讯作者：
Di Biase, Matteo
中科院分区：
文献类型：
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作者：
Correale, Michele;Brunetti, Natale Daniele;Di Biase, Matteo
动脉粥样硬化机制的研究已经确定炎症在急性冠状动脉综合征（ACS）的发生、进展和结局中起着核心作用。ACS患者血浆c反应蛋白（CRP）水平升高。心肺复苏术是ACS、血管成形术后和梗死后患者长期治疗的重要预后指标。尽管CRP仍将是一个有用的标志物，但其他急性期蛋白（APPs）血浆浓度升高的作用和意义，如α -1抗胰蛋白酶（AIAT）、α -1糖蛋白（AIGP）、接触珠蛋白（HG）、铜蓝蛋白（CP）、C3c和C4补体分数，在ACS患者中仍未完全确定。本文就这些app在ACS中的作用及其生物学和临床意义的实验和临床证据进行综述。
Investigation of the mechanisms of atherosclerosis has determined that inflammation plays a central role in the development, progression, and outcome of acute coronary syndrome (ACS). C-reactive protein (CRP) plasma levels increase in patients with ACS. CPR is an important prognostic marker in ACS, following angioplasty, and in the long-term management of post-infarction patients. Although CRP will remain over time a useful marker, the role and implications of increased plasma concentrations of other acute phase proteins (APPs), such as alpha-1-antitrypsin (AIAT), alpha-1 glycoprotein (AIGP), haptoglobin (HG), ceruloplasmin (CP), and C3c and C4 complement fraction, in patients with ACS are still not completely defined. This short review summarizes the experimental and clinical evidence regarding the role, and the biological and clinical significance of these other APPs in ACS.