Polycystic ovary syndrome as a form of functional ovarian hyperandrogenism due to dysregulation of androgen secretion.
Polycystic ovary syndrome as a form of functional ovarian hyperandrogenism due to dysregulation of androgen secretion.
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DOI：
10.1210/edrv-16-3-322
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发表时间：
1995-06
影响因子：
20.3
通讯作者：
D. Ehrmann;R. Barnes;R. Rosenfield
中科院分区：
文献类型：
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作者：
D. Ehrmann;R. Barnes;R. Rosenfield
I. 历史和术语：从 Stein-Leventhal 到功能性卵巢雄激素过多症 (FOH) 1935 年，Stein 和 Leventhal (1) 报告了女性多囊卵巢与闭经、多毛症和肥胖之间的关联。对这些患者卵巢的形态学和组织学研究显示，白膜增厚、内膜和皮质间质增生，以及多个处于闭锁不同阶段的囊下卵泡 (1)。随后，多囊卵巢女性卵巢组织学和临床表现的异质性得到认识，并导致多囊卵巢综合征 (PCOS) 一词的建立 (2, 3)。事实上，病情最严重的患者可能患有卵泡细胞增多症，这是一种没有囊肿的形式 (2,4,5)，而卵巢功能较轻的患者往往具有正常的卵巢形态 (6)。后来，血清 LH 浓度升高或 LH 与 FSH 比率升高被证明是特征性的 (7)，并成为常见病...
I. History and Terminology: From Stein-Leventhal toFunctional Ovarian Hyperandrogenism (FOH) IN 1935, Stein and Leventhal (1) reported the association of polycystic ovaries in women with amenorrhea, hirsutism, and obesity. Morphological and histological studies of the ovaries from these patients revealed a thickened tunica albuginea, hyperplasia of the theca interna and cortical stroma, and multiple subcapsular follicles that were in various stages of atresia (1). Subsequently, the heterogeneity of both the ovarian histology and clinical findings in women with polycystic ovaries was recognized and led to the establishment of the term polycystic ovary syndrome (PCOS) (2, 3). Indeed, patients with the severest cases may have hyperthecosis, a form in which there are no cysts (2,4,5), and those with milder ovarian dysfunction tend to have normal ovarian morphology (6). Later, increased concentrations of serum LH or an increase in the ratio of LH to FSH were shown to be characteristic (7) and became common dia...