Clonal Expansion of Biofilm-Forming Salmonella Typhimurium ST34 with Multidrug-Resistance Phenotype in the Southern Coastal Region of China.
Clonal Expansion of Biofilm-Forming Salmonella Typhimurium ST34 with Multidrug-Resistance Phenotype in the Southern Coastal Region of China.
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DOI：
10.3389/fmicb.2017.02090
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发表时间：
2017
影响因子：
5.2
通讯作者：
Hu Q
中科院分区：
文献类型：
--
作者：
Li W;Li Y;Liu Y;Shi X;Jiang M;Lin Y;Qiu Y;Zhang Q;Chen Q;Zhou L;Sun Q;Hu Q
为揭示常见基因型鼠伤寒沙门氏菌对抗生素的敏感性和广泛适应性，对240株不同MLST型鼠伤寒沙门氏菌进行了耐药性和生物膜形成的研究。对深圳市2010-2014年分离的33株食源性和207株临床分离的鼠伤寒沙门氏菌进行分析。其中ST 34型167株（69.58%），ST 19型57株（23.75%）。ST 34菌株有159株（95.21%）表现出多重耐药表型（≥ 3种抗生素），而ST 19菌株只有23株（40.35%）表现出多重耐药表型（≥ 3种抗生素）（P < 0.01）。ST 34菌株中有较高比例（72.46%）属于中强生物膜形成菌，而ST 19菌株中只有15.79%属于中强生物膜形成菌（P < 0.01）。在食品分离株中，超过一半（51.52%）来自畜产品，其中41.18%属于中度至强生物膜产生菌。总之，本研究强调了S。我国南方沿海地区存在一株生物被膜形成能力强、耐多药的鼠伤寒沙门氏菌ST 34。因此，监测ST 34 S.食品中的鼠伤寒沙门氏菌，特别是畜产品中的鼠伤寒沙门氏菌，并采取适当措施控制沙门氏菌。应解决通过减少生物膜形成的感染。
To disclose the antibiotics susceptibility and wide adaptability of commonly occurring genotypes of Salmonella Typhimurium, the antibiotic resistance and biofilm formation of different multi-locus sequence typing (MLST) types of a collection of 240 S. Typhimurium isolates (33 food and 207 clinical ones) during 2010–2014 in Shenzhen were analyzed. Among these strains, 167 was ST34 (69.58%), and 57 was ST19 (23.75%), respectively. A total of 159 (95.21%) ST34 strains displayed the multidrug resistant phenotype (≥ three classes of antibiotic), whereas only 23 (40.35%) ST19 ones did (P < 0.01). Moreover, a relative high proportion (72.46%) of ST34 isolates was classified as moderate to strong biofilm-producers, while only 15.79% of ST19 (P < 0.01) was. Among the food isolates, more than half (51.52%) were from livestock products, among which 41.18% classified as moderate to strong biofilm-producers. In summary, this study highlights the expansion of S. Typhimurium ST34 of strong biofilm-forming ability and multidrug resistance in the southern coastal region of China. Therefore, monitoring the occurrence of ST34 S. Typhimurium in food sources, especially in livestock products, and taking appropriate measures to control Salmonella spp. infections via decreasing biofilm formation should be addressed.